ARPC4
Gene Information
- Official Symbol: ARPC4
- Official Name: actin related protein 2/3 complex subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 10093
- UniProt: P59998
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.
Pfam Domains GO Terms
Pfam Domains
| ARPC4 |
GO Terms
| Arp2/3 protein complex |
| Arp2/3 complex-mediated actin nucleation |
| actin filament polymerization |
| actin nucleation |
| actin polymerization or depolymerization |
| site of double-strand break |
| protein binding, bridging |
| protein polymerization |
| ephrin receptor signaling pathway |
| positive regulation of actin filament polymerization |
| cell projection |
| structural constituent of cytoskeleton |
| positive regulation of protein polymerization |
| immune response-regulating cell surface receptor signaling pathway involved in phagocytosis |
| Fc-gamma receptor signaling pathway involved in phagocytosis |
| Fc receptor mediated stimulatory signaling pathway |
| Fc-gamma receptor signaling pathway |
| regulation of actin filament polymerization |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| actin filament binding |
| positive regulation of cytoskeleton organization |
| regulation of protein polymerization |
| actin filament organization |
| Fc receptor signaling pathway |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| phagocytosis |
| regulation of actin cytoskeleton organization |
| enzyme binding |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| immune response-activating cell surface receptor signaling pathway |
| regulation of protein complex assembly |
| supramolecular fiber organization |
| immune response-regulating cell surface receptor signaling pathway |
| actin cytoskeleton organization |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| immune response-activating signal transduction |
| actin filament-based process |
| immune response-regulating signaling pathway |
| positive regulation of organelle organization |
| activation of immune response |
| enzyme linked receptor protein signaling pathway |
| cellular protein-containing complex assembly |
| membrane organization |
| positive regulation of immune response |
| regulation of cellular component biogenesis |
| immune effector process |
| cytoskeleton organization |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| protein-containing complex assembly |
| regulation of immune system process |
| protein-containing complex subunit organization |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ARPC2 | 0.743 |
| ACTR2 | 0.724 |
| ACTR3 | 0.678 |
| COMMD5 | 0.646 |
| COMMD3 | 0.588 |
| CCDC22 | 0.569 |
| VPS29 | 0.568 |
| COMMD7 | 0.565 |
| COMMD10 | 0.534 |
| COMMD9 | 0.512 |
| CHKA | 0.504 |
| KIAA0196 | 0.5 |
| COMMD2 | 0.482 |
| RAB7A | 0.465 |
| COMMD4 | 0.459 |
| ACSL4 | 0.459 |
| USP32 | 0.453 |
| CCDC53 | 0.449 |
| MMD | 0.448 |
| ARPC3 | 0.448 |
| KIAA1033 | 0.447 |
| NCKAP1L | 0.443 |
| VPS45 | 0.436 |
| VKORC1L1 | 0.43 |
| GPR107 | 0.429 |
| FLVCR1 | 0.427 |
| MTMR9 | 0.419 |
| PCYT2 | 0.406 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 123/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 9/28 |
| blood | 1/28 |
| bone | 1/26 |
| breast | 2/33 |
| central nervous system | 9/56 |
| cervix | 0/4 |
| colorectal | 4/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 7/21 |
| liver | 9/20 |
| lung | 9/75 |
| lymphocyte | 2/16 |
| ovary | 8/26 |
| pancreas | 3/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 4/9 |
| thyroid | 0/2 |
| upper aerodigestive | 4/22 |
| urinary tract | 9/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 2076
- Expression level (log2 read counts): 6.62
Expression Distribution
ARPC4 Expression in NALM6 Cells: 6.62
