BCL2L11
Gene Information
- Official Symbol: BCL2L11
- Official Name: BCL2 like 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 10018
- UniProt: O43521
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Bim N |
| Bclx interact |
GO Terms
| positive regulation of autophagy in response to ER overload |
| positive regulation of apoptotic process by virus |
| cellular process regulating host cell cycle in response to virus |
| disruption by symbiont of host cell |
| positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction |
| positive regulation by symbiont of host apoptotic process |
| apoptotic process involved in embryonic digit morphogenesis |
| positive regulation by symbiont of host programmed cell death |
| killing by symbiont of host cells |
| modulation by virus of host apoptotic process |
| thymocyte apoptotic process |
| Bcl-2 family protein complex |
| modulation by organism of apoptotic process in other organism involved in symbiotic interaction |
| protein insertion into mitochondrial membrane involved in apoptotic signaling pathway |
| modulation of apoptotic process in other organism |
| modulation of programmed cell death in other organism |
| modulation by symbiont of host apoptotic process |
| modulation of programmed cell death in other organism involved in symbiotic interaction |
| positive regulation of IRE1-mediated unfolded protein response |
| B cell apoptotic process |
| modulation by symbiont of host programmed cell death |
| post-embryonic animal organ morphogenesis |
| positive regulation of fibroblast apoptotic process |
| positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| positive regulation of protein homooligomerization |
| ER overload response |
| post-embryonic animal morphogenesis |
| regulation of IRE1-mediated unfolded protein response |
| killing of cells in other organism involved in symbiotic interaction |
| positive regulation of endoplasmic reticulum unfolded protein response |
| disruption of cells of other organism involved in symbiotic interaction |
| T cell apoptotic process |
| mitochondrial outer membrane permeabilization |
| positive regulation of killing of cells of other organism |
| regulation of developmental pigmentation |
| post-embryonic animal organ development |
| positive regulation of mitochondrial membrane permeability involved in apoptotic process |
| apoptotic process involved in morphogenesis |
| regulation of fibroblast apoptotic process |
| regulation of killing of cells of other organism |
| modulation by virus of host cellular process |
| lymphocyte apoptotic process |
| mitochondrial outer membrane permeabilization involved in programmed cell death |
| regulation of protein homooligomerization |
| protein insertion into mitochondrial membrane |
| positive regulation of mitochondrial membrane permeability |
| regulation of mitochondrial membrane permeability involved in apoptotic process |
| positive regulation of membrane permeability |
| leukocyte apoptotic process |
| positive regulation of protein oligomerization |
| B cell homeostasis |
| regulation of endoplasmic reticulum unfolded protein response |
| modulation by symbiont of host cellular process |
| apoptotic process involved in development |
| positive regulation of release of cytochrome c from mitochondria |
| extrinsic apoptotic signaling pathway in absence of ligand |
| signal transduction in absence of ligand |
| regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| cellular response to virus |
| modulation by virus of host morphology or physiology |
| T cell homeostasis |
| spleen development |
| cellular response to estradiol stimulus |
| ER-nucleus signaling pathway |
| positive regulation of response to endoplasmic reticulum stress |
| protein insertion into membrane |
| cellular response to amyloid-beta |
| developmental pigmentation |
| modification by symbiont of host morphology or physiology |
| regulation of protein oligomerization |
| thymus development |
| regulation of release of cytochrome c from mitochondria |
| response to amyloid-beta |
| disruption of cells of other organism |
| killing of cells of other organism |
| lymphocyte homeostasis |
| positive regulation of neuron apoptotic process |
| cellular response to glucocorticoid stimulus |
| positive regulation of intrinsic apoptotic signaling pathway |
| apoptotic mitochondrial changes |
| cellular response to corticosteroid stimulus |
| embryonic digit morphogenesis |
| extrinsic component of membrane |
| positive regulation of cell killing |
| leukocyte homeostasis |
| establishment of protein localization to mitochondrion |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of mitochondrial membrane permeability |
| endomembrane system |
| protein localization to mitochondrion |
| regulation of membrane permeability |
| odontogenesis of dentin-containing tooth |
| regulation of response to endoplasmic reticulum stress |
| post-embryonic development |
| cell killing |
| pigmentation |
| positive regulation of neuron death |
| regulation of organ growth |
| extrinsic apoptotic signaling pathway |
| regulation of cell killing |
| myeloid cell homeostasis |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| positive regulation of mitochondrion organization |
| odontogenesis |
| positive regulation of autophagy |
| embryonic appendage morphogenesis |
| embryonic limb morphogenesis |
| cell-matrix adhesion |
| mitochondrial membrane organization |
| mammary gland development |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| male gonad development |
| development of primary male sexual characteristics |
| response to estradiol |
| response to glucocorticoid |
| tube formation |
| intrinsic apoptotic signaling pathway |
| limb morphogenesis |
| appendage morphogenesis |
| positive regulation of cysteine-type endopeptidase activity |
| modification of morphology or physiology of other organism |
| interaction with host |
| male sex differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| response to corticosteroid |
| mitochondrial outer membrane |
| positive regulation of endopeptidase activity |
| positive regulation of apoptotic signaling pathway |
| regulation of mitochondrion organization |
| limb development |
| appendage development |
| cell-substrate adhesion |
| cellular response to steroid hormone stimulus |
| positive regulation of peptidase activity |
| homeostasis of number of cells |
| regulation of neuron apoptotic process |
| gonad development |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| mitochondrial transport |
| cellular response to biotic stimulus |
| development of primary sexual characteristics |
| regulation of symbiosis, encompassing mutualism through parasitism |
| ear development |
| microtubule binding |
| regulation of cysteine-type endopeptidase activity |
| positive regulation of protein complex assembly |
| response to endoplasmic reticulum stress |
| establishment of protein localization to membrane |
| sex differentiation |
| kidney development |
| response to virus |
| renal system development |
| apoptotic signaling pathway |
| regulation of neuron death |
| urogenital system development |
| cellular response to peptide |
| response to steroid hormone |
| regulation of developmental growth |
| regulation of autophagy |
| positive regulation of proteolysis |
| positive regulation of cellular catabolic process |
| in utero embryonic development |
| positive regulation of cell cycle |
| regulation of apoptotic signaling pathway |
| gland development |
| regulation of endopeptidase activity |
| reproductive structure development |
| reproductive system development |
| positive regulation of catabolic process |
| establishment of protein localization to organelle |
| mitochondrion organization |
| regulation of peptidase activity |
| regulation of protein complex assembly |
| protein kinase binding |
| response to peptide |
| protein localization to membrane |
| protein heterodimerization activity |
| positive regulation of multi-organism process |
| cellular response to lipid |
| positive regulation of cellular component biogenesis |
| cellular response to organic cyclic compound |
| spermatogenesis |
| sensory organ development |
| male gamete generation |
| embryonic morphogenesis |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| chordate embryonic development |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| regulation of growth |
| gamete generation |
| positive regulation of cell death |
| viral process |
| regulation of proteolysis |
| protein localization to organelle |
| regulation of cellular response to stress |
| brain development |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| cellular response to DNA damage stimulus |
| head development |
| symbiotic process |
| interspecies interaction between organisms |
| multicellular organismal reproductive process |
| sexual reproduction |
| regulation of cellular catabolic process |
| multicellular organism reproduction |
| tube development |
| response to lipid |
| membrane organization |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| cell adhesion |
| biological adhesion |
| animal organ morphogenesis |
| regulation of cellular component biogenesis |
| embryo development |
| central nervous system development |
| multi-organism reproductive process |
| regulation of catabolic process |
| response to organonitrogen compound |
| positive regulation of intracellular signal transduction |
| programmed cell death |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| cell death |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| mitochondrion |
| regulation of hydrolase activity |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| establishment of protein localization |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of molecular function |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14765
- Expression level (log2 read counts): 6.42
Expression Distribution
BCL2L11 Expression in NALM6 Cells: 6.42
