CARM1

Gene Information

Official Symbol: CARM1
Official Name: coactivator associated arginine methyltransferase 1
Aliases and Previous Symbols: N/A
Entrez ID: 10498
UniProt: Q86X55
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families, methylates histone H3 at 'Arg-17' (H3R17me), forming mainly asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation, acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1, NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation, acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation, acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG, promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300, both at 'Arg- 2142', which may loosen its interaction with NCOA2/GRIP1, and at 'Arg-580' and 'Arg-604' in the KIX domain, which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1, ELAVL1 and ELAV4, which may affect their mRNA- stabilizing properties and the half-life of their target mRNAs. {ECO:0000269|PubMed:16497732, ECO:0000269|PubMed:19405910}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
LY2090314 0.003μM R08 exp499	-2.91
Cerivastatin 0.15μM R05 exp226	-2.9
Benzoate 10000μM R08 exp455	-2.48
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.4
Lead acetate 2000μM R08 exp497	-2.35
UM0125461 0.74μM R02 exp84	-2.32
Fluvastatin 2.2μM R06 exp282	-2.29
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-2.19
Arsenate 40μM R06 exp264	-2.02
THZ531 0.11μM R07 exp409	-1.99
proTAME 5μM R04 exp187	-1.98
ML-792 0.2μM R08 exp505	-1.97
NFN1 0.4μM R03 exp99	-1.96
LY2090314 0.003μM R08 exp500 no dilution day6	-1.91
Apcin 25μM plus proTAME 2μM R04 exp177	-1.89
Docosahexaenoic-acid 50μM R07 exp356	-1.84
MS023 2μM R03 exp134	-1.83
Thapsigargin 0.005μM R07 exp407	-1.83
5-Azacytidine 2μM R07 exp330	-1.8
Pomalidomide 20μM R07 exp391	-1.8
Alpha-Amanitin 0.5μM R00 exp5	-1.79
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.71
AICAR 240μM R05 exp211	1.72
TRAIL 5ng/ml R00 exp35	1.82
GSK591 2.6μM R03 exp128	1.83
GSK461364A 0.005μM R03 exp125	1.93
Clomiphene 4.4μM R02 exp68	1.96
TRAIL 50ng/ml R00 exp36	1.97
Bafilomycin-A1 0.009μM R08 exp454	2.17
Vemurafenib 6.6μM R02 exp89	3.5
Diepoxybutane 3μM R07 exp354	3.53
Vemurafenib 6.6μM R08 exp434	4.2

Global Fraction of Cell Lines Where Essential: 7/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	1/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8114
Expression level (log2 read counts): 6.23

Expression Distribution