HSPA4
Gene Information
- Official Symbol: HSPA4
- Official Name: heat shock protein family A (Hsp70) member 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 3308
- UniProt: P34932
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HSP70 |
| MreB Mbl |
GO Terms
| protein insertion into mitochondrial outer membrane |
| outer mitochondrial membrane organization |
| establishment of protein localization to mitochondrial membrane |
| chaperone-mediated protein complex assembly |
| protein insertion into mitochondrial membrane |
| protein insertion into membrane |
| protein targeting to mitochondrion |
| establishment of protein localization to mitochondrion |
| protein localization to mitochondrion |
| mitochondrial membrane organization |
| protein import |
| response to unfolded protein |
| response to topologically incorrect protein |
| mitochondrial transport |
| establishment of protein localization to membrane |
| protein targeting |
| establishment of protein localization to organelle |
| mitochondrion organization |
| protein localization to membrane |
| protein localization to organelle |
| cellular protein-containing complex assembly |
| membrane organization |
| intracellular protein transport |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| protein-containing complex assembly |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| establishment of localization in cell |
| nitrogen compound transport |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11694
- Expression level (log2 read counts): 7.9
Expression Distribution
HSPA4 Expression in NALM6 Cells: 7.9
