MPHOSPH10
Gene Information
- Official Symbol: MPHOSPH10
- Official Name: M-phase phosphoprotein 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 10199
- UniProt: O00566
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Pfam Domains GO Terms
Pfam Domains
| Mpp10 |
GO Terms
| Mpp10 complex |
| small nucleolar ribonucleoprotein complex |
| small-subunit processome |
| negative regulation of phosphatase activity |
| negative regulation of dephosphorylation |
| chromosome |
| regulation of phosphatase activity |
| regulation of dephosphorylation |
| rRNA processing |
| rRNA metabolic process |
| ribosome biogenesis |
| RNA splicing, via transesterification reactions |
| ncRNA processing |
| RNA splicing |
| negative regulation of hydrolase activity |
| ribonucleoprotein complex biogenesis |
| ncRNA metabolic process |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of catalytic activity |
| nucleolus |
| RNA processing |
| negative regulation of molecular function |
| regulation of hydrolase activity |
| RNA binding |
| RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GOLGA6L1 | 0.547 |
| POLR2J3 | 0.51 |
| TCEB3C | 0.502 |
| TCEB3CL | 0.492 |
| KRT78 | 0.478 |
| ORC6 | 0.471 |
| TICRR | 0.471 |
| TCEB3CL2 | 0.469 |
| EBNA1BP2 | 0.46 |
| RPL35 | 0.457 |
| COX7A2L | 0.452 |
| POLE | 0.448 |
| C14orf93 | 0.443 |
| SART1 | 0.439 |
| PRIM1 | 0.438 |
| RPS3A | 0.436 |
| C1QTNF9B | 0.434 |
| POLA2 | 0.433 |
| CDCA3 | 0.433 |
| SSH2 | 0.431 |
| PSMD3 | 0.429 |
| SLC7A6OS | 0.428 |
| SLC6A17 | 0.428 |
| RPP40 | 0.427 |
| RPS19 | 0.42 |
| SLC4A1 | 0.42 |
| TBC1D3F | 0.416 |
| COL2A1 | 0.415 |
| UPF1 | 0.414 |
| CLCN6 | 0.414 |
| PSMB2 | 0.41 |
| COL25A1 | 0.409 |
| TWISTNB | 0.407 |
| MFSD12 | 0.406 |
| SUPT5H | 0.403 |
| MCOLN1 | 0.403 |
| TBC1D3C | 0.403 |
| ANKLE2 | 0.402 |
| CDH24 | 0.401 |
| CHD4 | 0.401 |
| TSG101 | 0.401 |
| PWP2 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 344/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 10/28 |
| blood | 12/28 |
| bone | 6/26 |
| breast | 12/33 |
| central nervous system | 28/56 |
| cervix | 2/4 |
| colorectal | 6/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 4/16 |
| kidney | 12/21 |
| liver | 8/20 |
| lung | 39/75 |
| lymphocyte | 10/16 |
| ovary | 13/26 |
| pancreas | 12/24 |
| peripheral nervous system | 5/16 |
| plasma cell | 6/15 |
| prostate | 0/1 |
| skin | 19/24 |
| soft tissue | 6/9 |
| thyroid | 0/2 |
| upper aerodigestive | 7/22 |
| urinary tract | 16/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 929
- Expression level (log2 read counts): 6.43
Expression Distribution
MPHOSPH10 Expression in NALM6 Cells: 6.43
