SKIV2L2
Gene Information
- Official Symbol: MTREX
- Official Name: Mtr4 exosome RNA helicase
- Aliases and Previous Symbols: N/A
- Entrez ID: 23517
- UniProt: P42285
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of exosome targeting complexes. Subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that directs a subset of non-coding short-lived RNAs for exosomal degradation. Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters (PubMed:27871484). May be involved in pre-mRNA splicing. Associated with the RNA exosome complex and involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA. {ECO:0000269|PubMed:17412707, ECO:0000269|PubMed:27871484}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 580
- Expression level (log2 read counts): 7.18
SKIV2L2 Expression in NALM6 Cells: 7.18
