SPCS2

Gene Information

Official Symbol: SPCS2
Official Name: signal peptidase complex subunit 2
Aliases and Previous Symbols: N/A
Entrez ID: 9789
UniProt: Q15005
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Gene	Correlation
EPRS	0.543
HSPD1	0.536
HARS	0.513
RNMT	0.501
GMPPB	0.492
MED16	0.48
CEP350	0.475
NARS	0.473
PELO	0.471
CSNK2B	0.467
DAD1	0.467
ALG2	0.467
MAD2L1	0.465
DPAGT1	0.464
DDOST	0.464
MEAF6	0.463
THG1L	0.462
SLC35B1	0.462
EIF4E	0.46
MARS	0.459
RPN1	0.456
SEH1L	0.456
PAM16	0.454
TTI2	0.45
YARS	0.449
SRP72	0.448
RTCB	0.448
NAE1	0.447
CCDC101	0.445
DHDDS	0.443
PMM2	0.441
POLR3B	0.441
RPTOR	0.439
POLR3H	0.436
GFPT1	0.435
ENY2	0.434
SEC61G	0.433
AARS	0.427
DDX20	0.425
TTI1	0.422
ALG14	0.42
RBM14	0.418
ALG1	0.417
VRK1	0.416
TBCD	0.415
DHPS	0.415
OSGEP	0.41
RPP21	0.41
UAP1	0.408
NXT1	0.406
GTF3C2	0.406
OTUD5	0.405
TRIAP1	0.404
ALG5	0.402
ADSL	0.401

Global Fraction of Cell Lines Where Essential: 236/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	8/28
blood	9/28
bone	11/26
breast	15/33
central nervous system	23/56
cervix	1/4
colorectal	5/17
esophagus	5/13
fibroblast	0/1
gastric	6/16
kidney	8/21
liver	9/20
lung	17/75
lymphocyte	4/16
ovary	4/26
pancreas	5/24
peripheral nervous system	8/16
plasma cell	4/15
prostate	0/1
skin	12/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 2349
Expression level (log2 read counts): 6.42

Expression Distribution