SPCS3

Entrez Summary: N/A
UniProt Summary: Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000269|PubMed:27499293}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 2μM R00 exp33	1.74
Rotenone 20μM R00 exp34	1.94

Global Fraction of Cell Lines Where Essential: 338/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	15/28
blood	10/28
bone	15/26
breast	13/33
central nervous system	37/56
cervix	2/4
colorectal	10/17
esophagus	3/13
fibroblast	0/1
gastric	11/16
kidney	9/21
liver	10/20
lung	33/75
lymphocyte	7/16
ovary	8/26
pancreas	6/24
peripheral nervous system	6/16
plasma cell	6/15
prostate	1/1
skin	15/24
soft tissue	3/9
thyroid	1/2
upper aerodigestive	6/22
urinary tract	14/29
uterus	1/5

Expression Distribution