USP37

Gene Information

Official Symbol: USP37
Official Name: ubiquitin specific peptidase 37
Aliases and Previous Symbols: N/A
Entrez ID: 57695
UniProt: Q86T82
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-2.58
BI-2536 0.02μM R03 exp96	-2.35
Dorsomorphin 5μM R07 exp357	-2.25
Atovaquone 15μM R08 exp451	-2.06
Palbociclib 1μM R07 exp382	-1.91
BML-284 0.09μM R08 exp460	-1.87
Actinomycin-D 0.001μM R00 exp3	-1.81
Rotenone 2μM R00 exp33	-1.73
Actinomycin-D 0.01μM R00 exp4	-1.7
Etoposide 1μM R00 exp19	-1.7
Alda-1 10μM R06 exp262	1.71
UNC1999 2μM R03 exp155	1.73
Dihydrosphingosine 8μM R08 exp476	1.78
Wortmannin 0.5μM R00 exp37	1.78
iCRT14 30μM R08 exp492	1.8
DABN 2μM R00 exp16	1.84
Deguelin 0.05μM R02 exp69	1.88
Hypoxia 5%O2 R04 exp191	1.91
ML-792 0.2μM R08 exp505	2
Rapamycin 1μM R00 exp29	2.04
Isonicotinamide 500μM R03 exp129	2.05
Nicotine 3000μM R08 exp510	2.05
Resveratrol 16μM R03 exp147	2.18
ETC-159 50μM R08 exp480	2.35
Lapatinib 5μM R01 exp47	2.58
UNC2400 2μM R03 exp156	2.68

Global Fraction of Cell Lines Where Essential: 41/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	2/28
blood	1/28
bone	1/26
breast	4/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	1/16
kidney	4/21
liver	0/20
lung	3/75
lymphocyte	1/16
ovary	1/26
pancreas	1/24
peripheral nervous system	1/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	2/29
uterus	1/5

Essentiality in NALM6

Essentiality Rank: 1931
Expression level (log2 read counts): 6.3

Expression Distribution