Table of Contents
Tubastatin-A 2.5μM R07 exp417
Mechanism of Action
Inhibits HDAC6 selectively
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Protein References
- PubChem Name: Tubastatin A
- Synonyms: N/A
- CAS #: 1252003-15-8
- PubChem CID: 49850262
- IUPAC: N-hydroxy-4-[(2-methyl-3,4-dihydro-1H-pyrido[4,3-b]indol-5-yl)methyl]benzamide
- INCHI Name: InChI=1S/C20H21N3O2/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25/h2-9,25H,10-13H2,1H3,(H,21,24)
- INCHI Key: GOVYBPLHWIEHEJ-UHFFFAOYSA-N
- Molecular Weight: 335.4
- Canonical SMILES: CN1CCC2=C(C1)C3=CC=CC=C3N2CC4=CC=C(C=C4)C(=O)NO
- Isomeric SMILES: N/A
- Molecular Formula: C20H21N3O2
Protein Supplier
- Supplier Name: Ark Pharm Inc.
- Catalog #: AK474023
- Lot #: WG0559127-180118001
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C20H21N3O2 336.17065; found 336.17258
Dose Response Curve
- Platform ID: Tubistatin_A
- Min: -5.8434; Max: 99.5541
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 1.4458 |
| IC30 | 1.9030 |
| IC40 | 2.4165 |
| IC50 | 3.0321 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 2.5µM
- Days of incubation: 8
- Doublings: 5.0
- Numbers of reads: 21923022
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 3/0 | Scores |
Tubastatin-A 2.5μM R07 exp417
Calcium Ionophore 0.4μM R07 exp342 vs Tubastatin-A 2.5μM R07 exp417
