Table of Contents

Mubritinib 0.2μM R01 exp48

Mechanism of Action

Inhibits HER2 (Erb2) EGFR receptor tyrosine kinase

Technical Notes

Protein References

  • PubChem Name: Mubritinib
  • Synonyms: TAK-165
  • CAS #: 366017-09-6
  • PubChem CID: 6444692
  • IUPAC: 4-[[4-[4-(triazol-1-yl)butyl]phenoxy]methyl]-2-[(E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1,3-oxazole
  • INCHI Name: InChI=1S/C25H23F3N4O2/c26-25(27,28)21-9-4-20(5-10-21)8-13-24-30-22(18-34-24)17-33-23-11-6-19(7-12-23)3-1-2-15-32-16-14-29-31-32/h4-14,16,18H,1-3,15,17H2/b13-8+
  • INCHI Key: ZTFBIUXIQYRUNT-MDWZMJQESA-N
  • Molecular Weight: 468.5
  • Canonical SMILES: C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)C=CC4=CC=C(C=C4)C(F)(F)F
  • Isomeric SMILES: C1=CC(=CC=C1CCCCN2C=CN=N2)OCC3=COC(=N3)/C=C/C4=CC=C(C=C4)C(F)(F)F
  • Molecular Formula: C25H23F3N4O2

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S2216
  • Lot #: N/A

Protein Characterization

  • LCMS: Tr 1.31 min, m/z 469+ [M+H]+

Dose Response Curve

  • Platform ID: MUTRITINIB
  • Min: -5.4651; Max: 38.1718





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
3/19ScoresViewViewViewViewView