Table of Contents
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53
Mechanism of Action
Inhibits class I, II, IV HDACs, chelates active site zinc ion
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
Technical Notes
Protein References
- PubChem Name: Vorinostat
- Synonyms: SAHA
- CAS #: 149647-78-9
- PubChem CID: 5311
- IUPAC: N'-hydroxy-N-phenyloctanediamide
- INCHI Name: InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
- INCHI Key: WAEXFXRVDQXREF-UHFFFAOYSA-N
- Molecular Weight: 264.32
- Canonical SMILES: C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
- Isomeric SMILES: N/A
- Molecular Formula: C14H20N2O3
Protein Supplier
- Supplier Name: Tocris Bioscience
- Catalog #: 4652
- Lot #: N/A
Protein Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C14H20N2O3 265.15467; found 265.15439
Dose Response Curve
Dose response curve not available.
Screen Summary
- Round: 01
- Dose: 20nM
- Days of incubation: 8
- Doublings: 7.1
- Numbers of reads: 9593321
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53 vs UM131593 0.1μM R01 exp58
NFN1 0.1μM R01 exp49 vs Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53
2-Methoxyestradiol 0.2μM R01 exp40 vs Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53
