FECH

Entrez Summary: The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010].
UniProt Summary: Catalyzes the ferrous insertion into protoporphyrin IX.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM0011500 10μM R05 exp246	-2.17
SB202190 10μM R03 exp148	-2.04
UM0011500 5μM R05 exp245	-1.88
SB203580 25μM R03 exp149	-1.84
SGC0649 7μM R03 exp150	-1.8
Nifuroxazide 5μM R03 exp102	-1.73
5-Fluorouracil 2μM R00 exp1	1.74
MS023 7μM R03 exp135	1.74
THZ1 0.06μM R08 exp531	1.76
Rifampicin 1μM R00 exp31	1.77
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	1.87
CAY10603 0.55μM R08 exp467	1.95
PU-H71 1μM R08 exp515	2
Dynasore 7μM R08 exp436	2.07
GSK626616 14μM R08 exp485	2.13
Dinaciclib 0.007μM R07 exp355	2.18
Benzoate 20000μM R08 exp456	2.25
QNZ 0.01μM R08 exp439	2.29
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.56
Staurosporine 0.02μM R08 exp524	2.58
CR131-b 0.005μM R08 exp474	2.7
Tubacin 1.6μM R07 exp416	2.84
Hippuristanol 0.12μM R08 exp488	2.88
Artemisinin 50μM R08 exp450	6.57

Global Fraction of Cell Lines Where Essential: 10/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ferrochelatase activity
protoporphyrinogen IX metabolic process
2 iron, 2 sulfur cluster binding
heme biosynthetic process
ferrous iron binding
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
porphyrin-containing compound metabolic process
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
cofactor biosynthetic process
response to light stimulus
mitochondrial matrix
mitochondrial inner membrane
generation of precursor metabolites and energy
cofactor metabolic process
response to radiation
response to abiotic stimulus
heterocycle biosynthetic process
aromatic compound biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process