NFS1

Entrez Summary: Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010].
UniProt Summary: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor. {ECO:0000269|PubMed:18650437}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Deferoxamine 11μM R07 exp350	-3.33
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-2.66
Cytochalasin-B 5μM R07 exp349	-2.51
Benzoate 20000μM R08 exp456	-2.31
Hydroxyurea 100μM R07 exp329	-2.26
VHL-ligand-1 20μM R07 exp421	-2.26
Mitomycin-C 0.06μM R08 exp503	-2.18
DABN 20μM R00 exp17	-2.15
Oligomycin-A 20μM R00 exp26	-2.13
BI-6727 0.04μM R03 exp98	-2.11
UM0125461 0.74μM R02 exp84	-2.05
Artemisinin 50μM R08 exp450	-1.99
GSK-J4 1.5μM R08 exp441	-1.98
Nocodazole 0.2μM R02 exp64	-1.94
PU-H71 1μM R08 exp515	-1.88
Actinomycin-D 0.001μM R00 exp3	-1.73
SB202190 10μM R03 exp148	-1.73
All-trans-Retinoic-Acid 40μM R07 exp334	-1.72
CFI-400945 25μM R08 exp469	-1.72
Adefovir 20μM R07 exp332	1.73
CyclicAMP 200μM R08 exp475	1.76
Taxol 0.002μM R01 exp54	1.77
CCT251545 20μM R07 exp326	1.78
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.79
A-395 10μM R05 exp218	1.94
MKC9989 10μM R03 exp133	2.14
NFN1 0.4μM R03 exp99	2.28

Global Fraction of Cell Lines Where Essential: 733/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	26/26
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	16/16
ovary	25/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	8/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	5/5

Expression Distribution

Gene	Correlation
SH3BP1	0.409
CACTIN	0.401

Beta elim lyase
Aminotran 5

cysteine desulfurase activity
iron incorporation into metallo-sulfur cluster
metal incorporation into metallo-sulfur cluster
[2Fe-2S] cluster assembly
Mo-molybdopterin cofactor metabolic process
Mo-molybdopterin cofactor biosynthetic process
prosthetic group metabolic process
molybdopterin cofactor metabolic process
molybdopterin cofactor biosynthetic process
iron-sulfur cluster binding
metallo-sulfur cluster assembly
iron-sulfur cluster assembly
sulfur amino acid metabolic process
pyridoxal phosphate binding
coenzyme biosynthetic process
cofactor biosynthetic process
coenzyme metabolic process
cellular amino acid metabolic process
sulfur compound metabolic process
mitochondrial matrix
cofactor metabolic process
organophosphate biosynthetic process
protein homodimerization activity
organophosphate metabolic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
heterocycle biosynthetic process
mitochondrion
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
protein-containing complex assembly
small molecule metabolic process
protein-containing complex subunit organization