Golgicide-A 2μM R03 exp121
Mechanism of Action
Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi
- Class / Subclass 1: Organelle Function / Vesicule Trafficking Inhibitor
Technical Notes
Compound References
- PubChem Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
- Synonyms: N/A
- CAS #: 1005036-73-6
- PubChem CID: 3154410
- IUPAC: 6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
- INCHI Name: InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2
- INCHI Key: NJZHEQOUHLZCOX-UHFFFAOYSA-N
- Molecular Weight: 284.3
- Canonical SMILES: C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
- Isomeric SMILES: N/A
- Molecular Formula: C17H14F2N2
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: G0923
- Lot #: 105M4619V
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H14F2N2 285.11978; found 285.11995
Dose Response Curve
Dose response curve not available.
Screen Summary
- Round: 03
- Dose: 2µM
- Days of incubation: 8
- Doublings: 7.9
- Numbers of reads: 13633891
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 1/0 | Scores |
Golgicide-A 2μM R03 exp121
Golgicide-A 2μM R03 exp121 vs PT-1 25μM R07 exp392
Golgicide-A 2μM R03 exp121 vs PFI-3 10μM R03 exp144
