Golgicide-A 4μM R03 exp122

Inhibits cis-Golgi ArfGEF, blocks secretion at ER-Golgi

PubChem Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Synonyms: N/A
CAS #: 1005036-73-6
PubChem CID: 3154410
IUPAC: 6,8-difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
INCHI Name: InChI=1S/C17H14F2N2/c18-11-7-14-12-4-1-5-13(12)16(10-3-2-6-20-9-10)21-17(14)15(19)8-11/h1-4,6-9,12-13,16,21H,5H2
INCHI Key: NJZHEQOUHLZCOX-UHFFFAOYSA-N
Molecular Weight: 284.3
Canonical SMILES: C1C=CC2C1C(NC3=C2C=C(C=C3F)F)C4=CN=CC=C4
Isomeric SMILES: N/A
Molecular Formula: C17H14F2N2

Dose response curve not available.

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
66/23	Scores	View	View	View	View	View

GO Term	Fold Change	Genes
zinc ion import into Golgi lumen	552.63	SLC30A5,SLC30A7
cytosol to Golgi apparatus transport	368.42	SLC30A5,SLC30A7
zinc ion import into organelle	207.24	SLC30A6,SLC30A5,SLC30A7
COPII-coated vesicle cargo loading	118.42	SEC23B,SAR1A,SEC31A
zinc ion transmembrane transporter activity	72.08	SLC30A6,SLC30A5,SLC30A7
zinc ion transmembrane transport	63.77	SLC30A6,SLC30A5,SLC30A7
zinc ion transport	61.40	SLC30A6,SLC30A5,SLC30A7
vesicle cargo loading	53.48	SEC23B,SAR1A,SEC31A
endoplasmic reticulum exit site	53.48	SEC23B,SAR1A,SEC31A
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	46.05	ARF4,ARF5,ERGIC1,KDELR2
ER to Golgi transport vesicle membrane	37.47	SEC23B,SAR1A,SEC31A,SLC30A5
COPII-coated ER to Golgi transport vesicle	37.26	SEC23B,SAR1A,SEC31A,ERGIC1,SLC30A5,CNIH4
endoplasmic reticulum to Golgi vesicle-mediated transport	35.37	ARF4,SEC23B,SAR1A,SEC31A,ERGIC1,KDELR2,RAB2A,CNIH4
endoplasmic reticulum-Golgi intermediate compartment	21.59	ERGIC1,ERP44,MTMR6,RAB2A,CNIH4
Golgi vesicle transport	18.09	ARF4,SEC23B,ARF5,SAR1A,SEC31A,ERGIC1,KDELR2,RAB2A,CNIH4
coated vesicle membrane	14.32	SEC23B,SAR1A,SEC31A,KDELR2,SLC30A5
coated vesicle	12.77	SEC23B,SAR1A,SEC31A,ERGIC1,KDELR2,SLC30A5,CNIH4
Golgi membrane	6.74	ARF4,ARFGAP1,ERGIC1,GALNT2,KDELR2,RAB2A,SLC30A5,SLC30A7
perinuclear region of cytoplasm	6.17	SEC23B,ARF5,SEC31A,GALNT2,MTMR6,EIF2AK3,SLC30A7,MTMR9

Screen	Correlation	Plot
Bortezomib 0.005μM R00 exp6	0.058	View
Dynasore 10μM R04 exp180	0.057	View

GO Term	Fold Change	Genes
negative regulation of TORC1 signaling	59.91	NPRL3,SZT2,PRKAA1,ITFG2
negative regulation of TOR signaling	37.21	NPRL3,SZT2,PRKAA1,ITFG2