Nicotinate 1000μM R03 exp140 [The Human Chemical-Genetic Interaction Map Project]

NAD precursor (a.k.a. niacin, vitamin B3)

Class / Subclass 1: Metabolism / Metabolite

Compound References

PubChem Name: Nicotinic acid
Synonyms: Nicotinic acid; Vitamin B3
CAS #: 59-67-6
PubChem CID: 938
IUPAC: pyridine-3-carboxylic acid
INCHI Name: InChI=1S/C6H5NO2/c8-6(9)5-2-1-3-7-4-5/h1-4H,(H,8,9)
INCHI Key: PVNIIMVLHYAWGP-UHFFFAOYSA-N
Molecular Weight: 123.11
Canonical SMILES: C1=CC(=CN=C1)C(=O)O
Isomeric SMILES: N/A
Molecular Formula: C6H5NO2

Compound Supplier

Supplier Name: Sigma-Aldrich
Catalog #: N4126
Lot #: 065K0177

Compound Characterization

HRMS (ESI-TOF) m/z: (M-H)- Calcd for C6 H5 N O2 122.02475; found 122.02472

Dose Response Curve

Platform ID: POTASSIUM-NICOTINATE
Min: -4.7237; Max: 10.9209

IC	Concentration (µM)
IC10	N/A
IC20	N/A
IC30	N/A
IC40	N/A
IC50	N/A
IC60	N/A
IC70	N/A
IC80	N/A
IC90	N/A

Screen Summary

Round: 03
Dose: 1000µM
Days of incubation: 8
Doublings: 7.9
Numbers of reads: 7271685

Sensitive/Resistant hits (FDR<0.05)	CRANKS	Score Plot	Top 30 Genes	Screen Similarity	Top 30 Sensitive GO terms	Top 30 Resistant GO terms
0/0	Scores	View	View	View	View	View

Gene	CRANKS Score	FDR
SNAPIN	-2.52	0.19
ZNF136	-2.47	0.19
STK10	-2.43	0.19
ZCRB1	-2.35	0.43
HGC6.3	-2.28	0.86
CDIPT	-2.28	0.86
CTBP2	-2.21	0.43
GCLC	-2.18	0.43
PPP1R9B	-2.17	0.43
YLPM1	-2.16	0.52
SLC29A2	-2.15	0.43
KLC2	-2.14	0.43
TRMT10A	-2.13	0.43
LRMP	-2.13	0.43
AKR1C2	-2.11	0.43
ITGBL1	-2.10	0.43
ARHGAP11B	-2.08	0.43
HSPH1	-2.06	0.48
PYROXD1	-2.05	0.86
HOXD1	-2.05	0.43
LEO1	-2.02	0.52
SEPSECS	-2.01	0.78
TAF6L	-2.01	0.43
ALDH18A1	-1.99	0.43
ABCA3	-1.96	0.48
SPRR3	-1.94	0.48
NUDT11	-1.89	0.78
OXSR1	-1.89	0.78
ASPHD2	-1.89	0.54
VPS25	-1.84	0.86
MED15	1.92	0.69
EIF3J	1.92	0.81
PSMB1	1.94	0.69
TIGD7	1.95	0.69
IER5L	1.96	0.69
HIST1H2BB	1.97	0.78
ZNF571	1.98	0.69
EXOSC8	2.05	0.69
DAPK1	2.09	0.36
MS4A13	2.09	0.81
BIRC5	2.10	0.78
PLEKHA2	2.10	0.69
TOP1MT	2.10	0.57
WBSCR22	2.15	0.78
MAP3K2	2.16	0.29
PREX2	2.18	0.29
SP8	2.18	0.29
IFT27	2.19	0.69
UBXN8	2.25	0.69
ADAM10	2.25	0.29
TPBG	2.27	0.30
TP53I11	2.30	0.29
SGSH	2.36	0.29
CD52	2.40	0.29
FAM163B	2.48	0.44
ISCU	2.49	0.78
ESPL1	2.49	0.69
MYO1H	2.51	0.29
RNF17	2.56	0.29
RPL10	2.62	0.29

Last modified: 2026/01/15 21:36
by 127.0.0.1