Myriocin 25μM R06 exp293

Mechanism of Action

Inhibits serine palmitoyltransferase (SPT1), sphingolipid biosynthesis

  • Class / Subclass 1: Infectious Disease / Antibiotic
  • Class / Subclass 2: Metabolism / Metabolic Enzyme Inhibitor

Technical Notes

Compound References

  • PubChem Name: Myriocin
  • Synonyms: N/A
  • CAS #: 35891-70-4
  • PubChem CID: 6438394
  • IUPAC: (E,2S,3R,4R)-2-amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxoicos-6-enoic acid
  • INCHI Name: InChI=1S/C21H39NO6/c1-2-3-4-10-13-17(24)14-11-8-6-5-7-9-12-15-18(25)19(26)21(22,16-23)20(27)28/h9,12,18-19,23,25-26H,2-8,10-11,13-16,22H2,1H3,(H,27,28)/b12-9+/t18-,19+,21+/m1/s1
  • INCHI Key: ZZIKIHCNFWXKDY-GNTQXERDSA-N
  • Molecular Weight: 401.5
  • Canonical SMILES: CCCCCCC(=O)CCCCCCC=CCC(C(C(CO)(C(=O)O)N)O)O
  • Isomeric SMILES: CCCCCCC(=O)CCCCCC/C=C/C[C@H]([C@@H]([C@@](CO)(C(=O)O)N)O)O
  • Molecular Formula: C21H39NO6

Compound Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: M1177
  • Lot #: N/A

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C21H39NO6 402.28501; found 402.28657

Dose Response Curve

  • Platform ID: Myriocin
  • Min: -22.5595; Max: 3.5656





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

  • Round: 06
  • Dose: 25µM
  • Days of incubation: 8
  • Doublings: 7.2
  • Numbers of reads: 8003920

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/0ScoresViewViewViewViewView

  • Last modified: 2026/01/15 21:36
  • by 127.0.0.1