Trichostatin-A 0.06μM R07 exp415
Mechanism of Action
Inhibits class I and II HDAC enzymes
- Class / Subclass 1: Gene Regulation / Epigenetic Inhibitor
- Class / Subclass 2: Infectious Disease / Antifungal
Technical Notes
Compound References
- PubChem Name: Trichostatin A
- Synonyms: TSA
- CAS #: 58880-19-6
- PubChem CID: 444732
- IUPAC: (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
- INCHI Name: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
- INCHI Key: RTKIYFITIVXBLE-QEQCGCAPSA-N
- Molecular Weight: 302.37
- Canonical SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- Isomeric SMILES: C[C@H](/C=C(\\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
- Molecular Formula: C17H22N2O3
Compound Supplier
- Supplier Name: Toronto Research Chemicals
- Catalog #: T774710
- Lot #: 1-JLM-53-1
Compound Characterization
- HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C17H22N2O3 303.17032; found 303.1712
Dose Response Curve
- Platform ID: Trichostatin_A
- Min: -6.6261; Max: 99.5126
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | 0.0475 |
| IC30 | 0.0559 |
| IC40 | 0.0645 |
| IC50 | 0.0740 |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 60nM
- Days of incubation: 8
- Doublings: 4.6
- Numbers of reads: 18763387
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 3/0 | Scores |
Trichostatin-A 0.06μM R07 exp415
Resminostat 0.5μM R07 exp393 vs Trichostatin-A 0.06μM R07 exp415
