Beta-Estradiol 0.55μM R07 exp425
Mechanism of Action
Agonist for estrogen receptor (ER), inactive control for 2-Methoxyestradiol
- Class / Subclass 1: Gene Regulation / Transcription Activator
- Class / Subclass 2: Metabolism / Hormone Agonist
Technical Notes
Compound References
- PubChem Name: Estradiol
- Synonyms: β-Estradiol; E2; 17β-Estradiol; 17β-Oestradiol
- CAS #: 50-28-2
- PubChem CID: 5757
- IUPAC: (8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
- INCHI Name: InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
- INCHI Key: VOXZDWNPVJITMN-ZBRFXRBCSA-N
- Molecular Weight: 272.4
- Canonical SMILES: CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
- Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
- Molecular Formula: C18H24O2
Compound Supplier
- Supplier Name: Sigma-Aldrich
- Catalog #: E-2758
- Lot #: 025K1075
Compound Characterization
- LCMS: Tr 1.23 min, m/z 255+ [M+H-H2O]+
Dose Response Curve
- Platform ID: 12-beta-estradiol
- Min: -11.4539; Max: 9.0892
| IC | Concentration (µM) |
|---|---|
| IC10 | N/A |
| IC20 | N/A |
| IC30 | N/A |
| IC40 | N/A |
| IC50 | N/A |
| IC60 | N/A |
| IC70 | N/A |
| IC80 | N/A |
| IC90 | N/A |
Screen Summary
- Round: 07
- Dose: 550nM
- Days of incubation: 8
- Doublings: 7.0
- Numbers of reads: 25360615
Screen Results
| Sensitive/Resistant hits (FDR<0.05) | CRANKS | Score Plot | Top 30 Genes | Screen Similarity | Top 30 Sensitive GO terms | Top 30 Resistant GO terms |
|---|---|---|---|---|---|---|
| 0/0 | Scores |
Beta-Estradiol 0.55μM R07 exp425
