ZNF574 [The Human Chemical-Genetic Interaction Map Project]

Gene Information

Official Symbol: ZNF574
Official Name: zinc finger protein 574
Aliases and Previous Symbols: N/A
Entrez ID: 64763
UniProt: Q6ZN55
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: May be involved in transcriptional regulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SB743921 0.001μM R05 exp244	-2
Resminostat 0.5μM R07 exp393	1.71
UM131593 0.1μM R01 exp58	1.75
IU1-47 25μM R04 exp182	1.77
Nocodazole 0.02μM R00 exp23	1.82
THZ531 0.11 to 0.175μM on day4 R07 exp413	1.83
BRD2 inhibitor II 20μM R07 exp341	1.86
Dihydrosphingosine 8μM R08 exp476	1.88
Curcumin 6.5μM R06 exp277	2.15
Doxycycline 10μM R00 exp18	2.34

Gene	Correlation
PRIM1	0.49
RPL35	0.485
C14orf93	0.471
TBC1D3I	0.46
TBC1D3E	0.459
TBC1D3L	0.458
TBC1D3K	0.458
DTL	0.454
TICRR	0.452
EXOSC9	0.45
DDX56	0.443
NOL12	0.442
TCEB3C	0.439
CHAF1A	0.438
RPL6	0.436
ACSF2	0.435
CCDC116	0.434
TBC1D3F	0.433
TBC1D3H	0.432
TBC1D3C	0.429
RPS12	0.425
GOLGA6L3	0.424
TBC1D3G	0.423
POLE	0.423
SNRPA1	0.42
PSMB4	0.419
TCEB3CL	0.419
COPG1	0.419
CHD4	0.419
SUPT5H	0.418
TBC1D3	0.415
TFIP11	0.414
HIST2H3A	0.414
HIST2H3C	0.414
C1QTNF9B	0.413
COPB1	0.412
PPM1D	0.411
NARFL	0.409
CBWD5	0.409
GPRIN2	0.409
ORC1	0.408
EBNA1BP2	0.408
TCEB3CL2	0.407
RPS5	0.406
MT1E	0.406
NFATC4	0.405
AAMP	0.404
COX7A2L	0.403
CBWD3	0.401

Global Fraction of Cell Lines Where Essential: 178/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	13/28
blood	7/28
bone	1/26
breast	5/33
central nervous system	8/56
cervix	0/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	4/16
kidney	8/21
liver	6/20
lung	15/75
lymphocyte	4/16
ovary	7/26
pancreas	6/24
peripheral nervous system	4/16
plasma cell	0/15
prostate	0/1
skin	8/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	4/5

Essentiality in NALM6

Essentiality Rank: 303
Expression level (log2 read counts): 4.84

Expression Distribution

Last modified: 2026/01/07 22:37
by 127.0.0.1