ASPM
Gene Information
- Official Symbol: ASPM
- Official Name: assembly factor for spindle microtubules
- Aliases and Previous Symbols: N/A
- Entrez ID: 259266
- UniProt: Q8IZT6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| CAMSAP CH |
| CH |
GO Terms
| negative regulation of asymmetric cell division |
| regulation of asymmetric cell division |
| maintenance of centrosome location |
| spindle assembly involved in meiosis |
| microtubule minus-end |
| forebrain neuroblast division |
| meiotic spindle |
| maintenance of organelle location |
| meiotic spindle organization |
| neuronal stem cell division |
| neuroblast division |
| negative regulation of cell division |
| positive regulation of neuroblast proliferation |
| neuronal stem cell population maintenance |
| somatic stem cell division |
| mitotic spindle pole |
| centrosome localization |
| microtubule organizing center localization |
| neuroblast proliferation |
| regulation of neuroblast proliferation |
| stem cell division |
| positive regulation of stem cell proliferation |
| spindle localization |
| regulation of meiotic cell cycle |
| positive regulation of neural precursor cell proliferation |
| stem cell proliferation |
| regulation of stem cell proliferation |
| forebrain generation of neurons |
| neural precursor cell proliferation |
| oogenesis |
| regulation of neural precursor cell proliferation |
| maintenance of location in cell |
| spindle assembly |
| cerebral cortex development |
| neuron migration |
| female gamete generation |
| male gonad development |
| stem cell population maintenance |
| development of primary male sexual characteristics |
| maintenance of cell number |
| positive regulation of canonical Wnt signaling pathway |
| meiotic nuclear division |
| spindle organization |
| male sex differentiation |
| midbody |
| regulation of reproductive process |
| maintenance of location |
| meiotic cell cycle process |
| regulation of cell division |
| pallium development |
| positive regulation of Wnt signaling pathway |
| calmodulin binding |
| gonad development |
| development of primary sexual characteristics |
| meiotic cell cycle |
| negative regulation of neuron differentiation |
| germ cell development |
| telencephalon development |
| sex differentiation |
| regulation of canonical Wnt signaling pathway |
| nuclear division |
| negative regulation of neurogenesis |
| organelle fission |
| negative regulation of nervous system development |
| apical plasma membrane |
| negative regulation of cell development |
| cellular process involved in reproduction in multicellular organism |
| regulation of Wnt signaling pathway |
| forebrain development |
| developmental growth |
| growth |
| reproductive structure development |
| reproductive system development |
| positive regulation of neurogenesis |
| microtubule cytoskeleton organization |
| centrosome |
| cell division |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| cell population proliferation |
| male gamete generation |
| organelle localization |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| microtubule-based process |
| gamete generation |
| negative regulation of cell differentiation |
| brain development |
| organelle assembly |
| head development |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| multi-organism reproductive process |
| cell cycle process |
| localization of cell |
| cell motility |
| cytoskeleton organization |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| locomotion |
| cell cycle |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| generation of neurons |
| movement of cell or subcellular component |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 14/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 1/20 |
| lung | 3/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 1/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 6896
- Expression level (log2 read counts): 9.23
Expression Distribution
ASPM Expression in NALM6 Cells: 9.23
