CCM2

Entrez Summary: This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
5-Azacytidine 2μM R07 exp330	-3.3
2-Deoxy-D-glucose 800μM R05 exp214	-3.14
Cerivastatin 0.15μM R05 exp226	-2.41
ML-792 0.2μM R08 exp505	-2.35
CR131-b 0.005μM R08 exp474	-2.23
Erlotinib 10μM R05 exp216	-2.22
Artemisinin 50μM R08 exp450	-2.18
Olaparib 4μM R08 exp512	-2.18
Cytochalasin-B 5μM R07 exp349	-2.14
Rapamycin 10μM R00 exp30	-2.14
CB-5083 0.4μM R08 exp468	-2.12
Wortmannin 5μM R00 exp38	-2.09
SNS-032 15μM R08 exp443	-2.04
Dynasore 7μM R08 exp436	-2.01
Fluvastatin 2.2μM R06 exp282	-1.94
JQ1 0.8μM R08 exp435	-1.94
MS023 2μM R03 exp134	-1.9
Talazoparib 0.006μM R06 exp299	-1.85
Dinaciclib 0.007μM R07 exp355	-1.84
Bafilomycin-A1 0.009μM R08 exp454	-1.83
Lead acetate 2000μM R08 exp498 no dilution day6	-1.81
PF-06409577 20μM R07 exp389	-1.77
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.77
Rapamycin 1μM R00 exp29	-1.7
R-DABN 8μM R03 exp111	1.7
SB743921 0.001μM R05 exp244	1.74
Nocodazole 0.2μM R00 exp24	1.79
Nocodazole 0.1μM R03 exp94	1.86
Nocodazole 0.2μM R02 exp64	1.88

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

blood vessel endothelial cell differentiation
venous blood vessel morphogenesis
endothelial tube morphogenesis
morphogenesis of an endothelium
venous blood vessel development
pericardium development
endothelial cell development
vasculogenesis
endothelial cell differentiation
multicellular organism growth
integrin-mediated signaling pathway
endothelium development
stress-activated MAPK cascade
cell-cell junction organization
stress-activated protein kinase signaling cascade
epithelial cell development
inner ear development
cell junction organization
ear development
epithelial tube morphogenesis
MAPK cascade
in utero embryonic development
developmental growth
growth
signal transduction by protein phosphorylation
blood vessel morphogenesis
morphogenesis of an epithelium
blood vessel development
vasculature development
cardiovascular system development
heart development
sensory organ development
tissue morphogenesis
protein-containing complex
chordate embryonic development
embryo development ending in birth or egg hatching
tube morphogenesis
epithelial cell differentiation
tube development
circulatory system development