DDX23

Entrez Summary: N/A
UniProt Summary: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. {ECO:0000269|PubMed:18425142}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Q15 2.7μM R02 exp79	-3.63
THZ531 0.225μM R08 exp444	-3.06
BI-6727 0.0125μM R03 exp97	-2.93
Monensin 0.3μM R08 exp507	-2.84
42°C R08 exp539	-2.44
CR131-b 0.005μM R08 exp474	-2.23
JQ1 0.8μM R08 exp435	-1.85
Palbociclib 1μM R07 exp382	-1.84
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.84
Cytochalasin-B 5μM R07 exp349	-1.83
BI-2536 0.02μM R03 exp96	-1.81
ML-792 0.2μM R08 exp505	-1.8
Vitamin-D3 40μM R08 exp536	-1.78
OICR-9429 10μM R03 exp142	-1.7
Vincristine 0.0005μM R04 exp190	1.78
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	1.8
CCT251545 0.2μM R06 exp271	1.82
Ribavirin 10 to 15μM on day4 R04 exp160	2.11
Etoposide 10μM R00 exp20	2.17
Tunicamycin 0.04μM R07 exp418	2.2

Global Fraction of Cell Lines Where Essential: 551/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	21/28
blood	20/28
bone	19/26
breast	25/33
central nervous system	47/56
cervix	3/4
colorectal	12/17
esophagus	9/13
fibroblast	1/1
gastric	12/16
kidney	12/21
liver	15/20
lung	56/75
lymphocyte	13/16
ovary	17/26
pancreas	18/24
peripheral nervous system	12/16
plasma cell	6/15
prostate	0/1
skin	17/24
soft tissue	7/9
thyroid	1/2
upper aerodigestive	17/22
urinary tract	21/29
uterus	3/5

Expression Distribution

DEAD
Helicase C

cis assembly of pre-catalytic spliceosome
U5 snRNP
mRNA cis splicing, via spliceosome
helicase activity
spliceosomal complex assembly
RNA helicase activity
catalytic step 2 spliceosome
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
mRNA metabolic process
cellular protein-containing complex assembly
nucleolus
RNA processing
RNA binding
ATP binding
protein-containing complex assembly
RNA metabolic process
protein-containing complex subunit organization
gene expression