ESPL1
Gene Information
- Official Symbol: ESPL1
- Official Name: extra spindle pole bodies like 1, separase
- Aliases and Previous Symbols: N/A
- Entrez ID: 9700
- UniProt: Q14674
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Caspase-like protease, which plays a central role in the chromosome segregation by cleaving the SCC1/RAD21 subunit of the cohesin complex at the onset of anaphase. During most of the cell cycle, it is inactivated by different mechanisms. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11509732}.
Pfam Domains GO Terms
Pfam Domains
| Peptidase C50 |
GO Terms
| negative regulation of sister chromatid cohesion |
| positive regulation of mitotic metaphase/anaphase transition |
| positive regulation of mitotic sister chromatid separation |
| positive regulation of metaphase/anaphase transition of cell cycle |
| positive regulation of chromosome separation |
| meiotic spindle organization |
| positive regulation of mitotic sister chromatid segregation |
| regulation of sister chromatid cohesion |
| meiotic chromosome separation |
| positive regulation of chromosome segregation |
| cysteine-type peptidase activity |
| chromosome separation |
| negative regulation of sister chromatid segregation |
| negative regulation of chromosome segregation |
| establishment of mitotic spindle localization |
| establishment of spindle localization |
| catalytic activity |
| spindle localization |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| positive regulation of mitotic nuclear division |
| homologous chromosome segregation |
| regulation of mitotic sister chromatid separation |
| regulation of chromosome separation |
| positive regulation of nuclear division |
| mitotic cytokinesis |
| regulation of mitotic sister chromatid segregation |
| positive regulation of mitotic cell cycle phase transition |
| mitotic spindle |
| regulation of sister chromatid segregation |
| meiotic chromosome segregation |
| cysteine-type endopeptidase activity |
| positive regulation of cell cycle phase transition |
| cytoskeleton-dependent cytokinesis |
| cytokinesis |
| regulation of chromosome segregation |
| microtubule cytoskeleton organization involved in mitosis |
| mitotic sister chromatid segregation |
| meiosis I |
| meiosis I cell cycle process |
| negative regulation of chromosome organization |
| sister chromatid segregation |
| mitotic nuclear division |
| positive regulation of mitotic cell cycle |
| meiotic nuclear division |
| spindle organization |
| meiotic cell cycle process |
| regulation of mitotic nuclear division |
| positive regulation of chromosome organization |
| regulation of nuclear division |
| nuclear chromosome segregation |
| meiotic cell cycle |
| chromosome segregation |
| nuclear division |
| positive regulation of cell cycle process |
| organelle fission |
| negative regulation of cell cycle process |
| regulation of chromosome organization |
| establishment of organelle localization |
| negative regulation of organelle organization |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| microtubule cytoskeleton organization |
| centrosome |
| cell division |
| negative regulation of cell cycle |
| organelle localization |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| microtubule-based process |
| mitotic cell cycle |
| negative regulation of cellular component organization |
| regulation of cell cycle process |
| apoptotic process |
| cell cycle process |
| programmed cell death |
| chromosome organization |
| cell death |
| cytoskeleton organization |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| proteolysis |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| CBWD5 | 0.404 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 724/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 25/25 |
| breast | 33/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 17/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 15/15 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 14/14 |
| ovary | 26/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 24/24 |
| soft tissue | 6/7 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 28/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 373
- Expression level (log2 read counts): 7.54
Expression Distribution
ESPL1 Expression in NALM6 Cells: 7.54
