FBXO5
Gene Information
- Official Symbol: FBXO5
- Official Name: F-box protein 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 26271
- UniProt: Q9UKT4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulates progression through early mitosis by inhibiting the anaphase promoting complex/cyclosome (APC). Binds to the APC activators CDC20 and FZR1/CDH1 to prevent APC activation. Can also bind directly to the APC to inhibit substrate-binding. {ECO:0000269|PubMed:11988738, ECO:0000269|PubMed:16921029}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| spindle assembly involved in female meiosis I |
| spindle assembly involved in female meiosis |
| regulation of mesenchymal stem cell migration |
| positive regulation of mesenchymal stem cell migration |
| ubiquitin ligase inhibitor activity |
| spindle assembly involved in meiosis |
| negative regulation of DNA endoreduplication |
| female meiosis I |
| anaphase-promoting complex binding |
| negative regulation of ubiquitin protein ligase activity |
| meiotic spindle |
| regulation of DNA endoreduplication |
| negative regulation of meiotic nuclear division |
| meiotic spindle organization |
| negative regulation of meiotic cell cycle |
| negative regulation of ubiquitin-protein transferase activity |
| negative regulation of cellular senescence |
| oocyte maturation |
| regulation of ubiquitin protein ligase activity |
| negative regulation of cell aging |
| negative regulation of mitotic metaphase/anaphase transition |
| negative regulation of metaphase/anaphase transition of cell cycle |
| negative regulation of DNA-dependent DNA replication |
| positive regulation of G2/M transition of mitotic cell cycle |
| negative regulation of mitotic sister chromatid separation |
| negative regulation of chromosome separation |
| regulation of transcription involved in G1/S transition of mitotic cell cycle |
| positive regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic sister chromatid segregation |
| female meiotic nuclear division |
| regulation of meiotic nuclear division |
| negative regulation of sister chromatid segregation |
| microtubule polymerization |
| negative regulation of chromosome segregation |
| oocyte development |
| negative regulation of DNA replication |
| negative regulation of mitotic nuclear division |
| regulation of cellular senescence |
| oocyte differentiation |
| positive regulation of biomineral tissue development |
| positive regulation of biomineralization |
| regulation of cell aging |
| negative regulation of nuclear division |
| regulation of meiotic cell cycle |
| microtubule polymerization or depolymerization |
| regulation of ubiquitin-protein transferase activity |
| regulation of mitotic metaphase/anaphase transition |
| regulation of metaphase/anaphase transition of cell cycle |
| regulation of DNA-dependent DNA replication |
| negative regulation of reproductive process |
| regulation of mitotic sister chromatid separation |
| positive regulation of osteoblast differentiation |
| regulation of chromosome separation |
| regulation of mitotic sister chromatid segregation |
| negative regulation of protein ubiquitination |
| positive regulation of mitotic cell cycle phase transition |
| oogenesis |
| negative regulation of response to DNA damage stimulus |
| regulation of sister chromatid segregation |
| anaphase-promoting complex-dependent catabolic process |
| negative regulation of protein modification by small protein conjugation or removal |
| positive regulation of ossification |
| protein polymerization |
| regulation of biomineral tissue development |
| regulation of biomineralization |
| positive regulation of cell cycle phase transition |
| spindle assembly |
| regulation of chromosome segregation |
| regulation of DNA replication |
| meiosis I |
| meiosis I cell cycle process |
| regulation of osteoblast differentiation |
| spindle |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| female gamete generation |
| negative regulation of chromosome organization |
| anatomical structure maturation |
| positive regulation of mitotic cell cycle |
| meiotic nuclear division |
| spindle organization |
| cell maturation |
| regulation of reproductive process |
| meiotic cell cycle process |
| regulation of mitotic nuclear division |
| regulation of ossification |
| regulation of nuclear division |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of protein ubiquitination |
| regulation of cell cycle G2/M phase transition |
| negative regulation of mitotic cell cycle phase transition |
| regulation of response to DNA damage stimulus |
| meiotic cell cycle |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of cell cycle phase transition |
| developmental maturation |
| germ cell development |
| mitotic cell cycle phase transition |
| negative regulation of transferase activity |
| cell cycle phase transition |
| nuclear division |
| positive regulation of cell cycle process |
| vesicle organization |
| negative regulation of mitotic cell cycle |
| organelle fission |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| negative regulation of cell cycle process |
| regulation of chromosome organization |
| proteasomal protein catabolic process |
| cellular process involved in reproduction in multicellular organism |
| negative regulation of organelle organization |
| positive regulation of cell cycle |
| regulation of mitotic cell cycle phase transition |
| regulation of cell cycle phase transition |
| supramolecular fiber organization |
| protein kinase binding |
| microtubule cytoskeleton organization |
| cell division |
| positive regulation of cell migration |
| positive regulation of cell motility |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| positive regulation of cellular component movement |
| modification-dependent macromolecule catabolic process |
| positive regulation of locomotion |
| negative regulation of cell cycle |
| proteolysis involved in cellular protein catabolic process |
| negative regulation of protein modification process |
| mitotic cell cycle process |
| cellular protein catabolic process |
| regulation of mitotic cell cycle |
| developmental process involved in reproduction |
| microtubule-based process |
| protein catabolic process |
| mitotic cell cycle |
| protein ubiquitination |
| gamete generation |
| negative regulation of cellular component organization |
| regulation of cellular response to stress |
| regulation of cell cycle process |
| organelle assembly |
| protein modification by small protein conjugation |
| negative regulation of catalytic activity |
| multicellular organismal reproductive process |
| sexual reproduction |
| cellular protein-containing complex assembly |
| multicellular organism reproduction |
| regulation of cell migration |
| cellular macromolecule catabolic process |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| multi-organism reproductive process |
| regulation of cellular component movement |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| negative regulation of protein metabolic process |
| cytoskeleton organization |
| negative regulation of molecular function |
| regulation of cell cycle |
| proteolysis |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| cell development |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| ZNF655 | 0.476 |
| SUPT6H | 0.469 |
| TWISTNB | 0.469 |
| VASN | 0.469 |
| PSMD1 | 0.466 |
| MYO1H | 0.465 |
| MED17 | 0.462 |
| RPS2 | 0.461 |
| ZNF106 | 0.459 |
| PSMC2 | 0.453 |
| TICRR | 0.447 |
| PRIM1 | 0.441 |
| PSMA6 | 0.439 |
| GPRIN2 | 0.437 |
| ZFAND5 | 0.437 |
| SCAF1 | 0.434 |
| SFPQ | 0.433 |
| STIL | 0.428 |
| RBBP5 | 0.426 |
| MED12 | 0.425 |
| C14orf93 | 0.423 |
| ATP6V0C | 0.419 |
| CHD4 | 0.415 |
| RANBP2 | 0.415 |
| UPF1 | 0.414 |
| PCF11 | 0.412 |
| MED14 | 0.412 |
| TBC1D3G | 0.411 |
| TOP1MT | 0.41 |
| HAP1 | 0.409 |
| PSMC4 | 0.408 |
| MYB | 0.405 |
| SMG1 | 0.405 |
| PSMB4 | 0.405 |
| ISCU | 0.404 |
| COX8A | 0.403 |
| DYNC1I2 | 0.403 |
| RPSA | 0.401 |
| ORC6 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 505/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 14/28 |
| bone | 15/26 |
| breast | 24/33 |
| central nervous system | 36/56 |
| cervix | 3/4 |
| colorectal | 14/17 |
| esophagus | 10/13 |
| fibroblast | 0/1 |
| gastric | 13/16 |
| kidney | 14/21 |
| liver | 7/20 |
| lung | 50/75 |
| lymphocyte | 9/16 |
| ovary | 21/26 |
| pancreas | 17/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 12/15 |
| prostate | 1/1 |
| skin | 18/24 |
| soft tissue | 8/9 |
| thyroid | 1/2 |
| upper aerodigestive | 13/22 |
| urinary tract | 23/29 |
| uterus | 4/5 |
Essentiality in NALM6
- Essentiality Rank: 1638
- Expression level (log2 read counts): 6.2
Expression Distribution
FBXO5 Expression in NALM6 Cells: 6.2
