GNA13

Gene Information

Official Symbol: GNA13
Official Name: G protein subunit alpha 13
Aliases and Previous Symbols: N/A
Entrez ID: 10672
UniProt: Q14344
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:15240885, PubMed:16787920, PubMed:16705036, PubMed:27084452). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG) (PubMed:15240885, PubMed:12515866). GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway (PubMed:16787920, PubMed:16705036, PubMed:27084452). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (PubMed:11976333). {ECO:0000250|UniProtKB:P27601, ECO:0000269|PubMed:11976333, ECO:0000269|PubMed:12515866, ECO:0000269|PubMed:15240885, ECO:0000269|PubMed:16705036, ECO:0000269|PubMed:16787920, ECO:0000269|PubMed:27084452}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Docetaxel 0.002μM R01 exp45	-3.66
Cabazitaxel 0.001μM R05 exp223	-3.47
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-3.12
Epothilone-B 0.0015μM R05 exp231	-3.04
Trimetrexate 0.03μM R08 exp535	-3.01
Rapamycin 2μM R07 exp306	-2.91
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2.81
All-trans-Retinoic-Acid 8μM R07 exp333	-2.69
Taxol 0.004μM R03 exp103	-2.64
Ethanol 0.01 R05 exp234	-2.57
AICAR 240μM R03 exp116	-2.48
Geldanamycin 0.015 to 0.025μM on day4 R07 exp316	-2.45
Rapamycin 1μM R00 exp29	-2.44
Rapamycin 0.001μM R08 exp429	-2.42
Citral 50μM R06 exp274	-2.38
Rapamycin 10μM R00 exp30	-2.04
Milciclib 2μM R08 exp502	-2.03
Dimethyl-Sulfoxide 1pc R03 exp120	-1.99
Amiloride 100μM R08 exp447	-1.93
LY2090314 0.003μM R08 exp500 no dilution day6	-1.93
Golgicide-A 4μM R03 exp122	-1.91
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.89
Vincristine 0.0005μM R04 exp190	-1.87
All-trans-Retinoic-Acid 40μM R07 exp334	-1.85
Colchicine 0.009μM R05 exp215	-1.84
UM0131023 0.05μM R05 exp248	-1.81
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.78
Pyridostatin 4μM R05 exp240	-1.78
ETC-159 50μM R08 exp480	-1.75
ZLN024 50μM R08 exp538	-1.75
I-BRD9 4μM R07 exp365	-1.74
LY2090314 0.003μM R08 exp499	-1.72
Temozolomide 200μM R04 exp189	-1.7
BI-6727 0.04μM R03 exp98	1.73
BI-2536 0.0042μM R03 exp95	1.85
Azithromycin 100μM R08 exp452	1.87
BI-6727 0.0125μM R03 exp97	1.87
MK-1775 0.32μM R02 exp75	1.88
Bafilomycin-A1 0.009μM R08 exp454	2.09
Cytochalasin-B 5μM R07 exp349	2.18
PF-06409577 20μM R07 exp389	2.24
VER-155008 3.9μM R06 exp301	2.52
Aminopterin 0.005μM R07 exp335	2.63
CR131-b 0.005μM R08 exp474	2.63
Chloroquine 32μM R08 exp470	2.66
Nicotine 3000μM R08 exp510	2.81
TRAIL 50ng/ml R00 exp36	2.85
TRAIL 5ng/ml R00 exp35	2.85
Bleomycin 5μM R08 exp459	4.38
Arsenate 40μM R06 exp264	5.15

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15299
Expression level (log2 read counts): 7.24

Expression Distribution

Gene	Correlation
ARHGEF1	0.736
RHOA	0.676
RIC8A	0.656
STRADA	0.473
STK11	0.457

Arf
G-alpha

D5 dopamine receptor binding
activation of phospholipase D activity
G-protein beta/gamma-subunit complex binding
branching involved in blood vessel morphogenesis
heterotrimeric G-protein complex
brush border membrane
positive regulation of phospholipase activity
G protein-coupled receptor binding
positive regulation of lipase activity
regulation of phospholipase activity
Rho protein signal transduction
regulation of lipase activity
melanosome
adenylate cyclase-activating G protein-coupled receptor signaling pathway
branching morphogenesis of an epithelial tube
platelet activation
cAMP-mediated signaling
regulation of cell shape
morphogenesis of a branching epithelium
morphogenesis of a branching structure
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Ras protein signal transduction
positive regulation of cytosolic calcium ion concentration
blood coagulation
coagulation
hemostasis
epithelial tube morphogenesis
angiogenesis
small GTPase mediated signal transduction
regulation of cytosolic calcium ion concentration
GTPase activity
second-messenger-mediated signaling
regulation of small GTPase mediated signal transduction
in utero embryonic development
GTP binding
blood vessel morphogenesis
focal adhesion
morphogenesis of an epithelium