HSP90B1
Gene Information
- Official Symbol: HSP90B1
- Official Name: heat shock protein 90 beta family member 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 7184
- UniProt: P14625
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity. {ECO:0000250, ECO:0000269|PubMed:18264092}.
Pfam Domains GO Terms
Pfam Domains
| HATPase c |
| HSP90 |
GO Terms
| actin rod assembly |
| sequestering of calcium ion |
| sarcoplasmic reticulum lumen |
| ATF6-mediated unfolded protein response |
| endoplasmic reticulum chaperone complex |
| endocytic vesicle lumen |
| protein folding in endoplasmic reticulum |
| cellular response to ATP |
| endoplasmic reticulum to cytosol transport |
| retrograde protein transport, ER to cytosol |
| low-density lipoprotein particle receptor binding |
| protein exit from endoplasmic reticulum |
| response to ATP |
| ER-nucleus signaling pathway |
| actin filament bundle assembly |
| actin filament bundle organization |
| cellular response to nutrient |
| ubiquitin-dependent ERAD pathway |
| protein phosphatase binding |
| ERAD pathway |
| toll-like receptor signaling pathway |
| melanosome |
| endoplasmic reticulum unfolded protein response |
| regulation of phosphoprotein phosphatase activity |
| cellular response to unfolded protein |
| pattern recognition receptor signaling pathway |
| unfolded protein binding |
| response to organophosphorus |
| regulation of protein dephosphorylation |
| cellular response to topologically incorrect protein |
| response to purine-containing compound |
| midbody |
| response to unfolded protein |
| maintenance of location |
| regulation of phosphatase activity |
| response to topologically incorrect protein |
| regulation of dephosphorylation |
| response to nutrient |
| protein folding |
| cellular response to nutrient levels |
| innate immune response-activating signal transduction |
| receptor-mediated endocytosis |
| actin filament organization |
| activation of innate immune response |
| response to endoplasmic reticulum stress |
| cellular response to extracellular stimulus |
| endoplasmic reticulum lumen |
| proteasome-mediated ubiquitin-dependent protein catabolic process |
| cellular response to external stimulus |
| positive regulation of innate immune response |
| response to hypoxia |
| proteasomal protein catabolic process |
| response to decreased oxygen levels |
| positive regulation of response to biotic stimulus |
| post-translational protein modification |
| collagen-containing extracellular matrix |
| response to oxygen levels |
| cellular response to drug |
| focal adhesion |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| regulation of innate immune response |
| supramolecular fiber organization |
| cellular divalent inorganic cation homeostasis |
| positive regulation of defense response |
| divalent inorganic cation homeostasis |
| actin cytoskeleton organization |
| response to nutrient levels |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| ubiquitin-dependent protein catabolic process |
| response to extracellular stimulus |
| modification-dependent protein catabolic process |
| cellular response to organic cyclic compound |
| modification-dependent macromolecule catabolic process |
| endocytosis |
| cellular metal ion homeostasis |
| immune response-activating signal transduction |
| actin filament-based process |
| proteolysis involved in cellular protein catabolic process |
| protein-containing complex |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cellular protein catabolic process |
| metal ion homeostasis |
| activation of immune response |
| cellular cation homeostasis |
| cellular ion homeostasis |
| cellular response to nitrogen compound |
| cytokine-mediated signaling pathway |
| import into cell |
| protein catabolic process |
| perinuclear region of cytoplasm |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| cellular chemical homeostasis |
| regulation of defense response |
| regulation of multi-organism process |
| ion homeostasis |
| positive regulation of immune response |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| response to organic cyclic compound |
| endoplasmic reticulum membrane |
| negative regulation of cell death |
| intracellular protein transport |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| endoplasmic reticulum |
| response to drug |
| macromolecule catabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| regulation of response to external stimulus |
| response to cytokine |
| cytoskeleton organization |
| chemical homeostasis |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| proteolysis |
| regulation of hydrolase activity |
| RNA binding |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| homeostatic process |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| organic substance catabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| regulation of protein modification process |
| nitrogen compound transport |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 29/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 0/28 |
| bone | 1/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 1/75 |
| lymphocyte | 0/16 |
| ovary | 1/26 |
| pancreas | 5/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 5/15 |
| prostate | 1/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6791
- Expression level (log2 read counts): 10.54
Expression Distribution
HSP90B1 Expression in NALM6 Cells: 10.54
