INTS12

Gene Information

Official Symbol: INTS12
Official Name: integrator complex subunit 12
Aliases and Previous Symbols: N/A
Entrez ID: 57117
UniProt: Q96CB8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (PubMed:16239144). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:23904267}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cryptotanshinone 12μM R05 exp227	-3.1
Bortezomib 0.005μM R00 exp6	-2.92
3-Bromopyruvate 7μM R04 exp175	-2.9
Deferoxamine 11μM R07 exp350	-2.88
LY2090314 0.003μM R08 exp500 no dilution day6	-2.72
THZ531 0.11μM R07 exp409	-2.58
Trichostatin-A 0.06μM R07 exp415	-2.54
Aphidicolin 0.4μM R08 exp440	-2.51
LLY-283 2.6μM R06 exp290	-2.45
Tunicamycin 0.04 to 0.125μM on day4 R07 exp420	-2.33
BML-284 0.09μM R08 exp460	-2.32
ABT-702 5μM plus CoCl2 18μM R07 exp320	-2.27
Erlotinib 10μM R05 exp216	-2.27
Milciclib 2μM R08 exp502	-2.26
JQ1 0.8μM R08 exp435	-2.24
Diepoxybutane 3μM R07 exp354	-2.22
Docosahexaenoic-acid 50μM R07 exp356	-2.19
Hydroxyurea 100μM R07 exp329	-2.18
THZ531 0.11 to 0.125μM on day4 R07 exp410	-2.13
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	-2.03
AICAR 240μM R05 exp211	-2.02
LY2090314 0.003μM R08 exp499	-2.01
Apcin 25μM plus proTAME 2μM R04 exp177	-1.98
5-Azacytidine 2μM R07 exp330	-1.97
Menadione 5μM R06 exp292	-1.97
Temozolomide 200μM R04 exp189	-1.94
THZ531 0.11 to 0.175μM on day4 R07 exp413	-1.94
CR131-b 0.005μM R08 exp474	-1.93
Dynasore 10μM R04 exp180	-1.87
Thimerosal 0.85μM R08 exp529	-1.86
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.84
UM131593 0.2μM R03 exp106	-1.84
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.81
PU-H71 1μM R08 exp515	-1.8
GSK591 2.6μM R03 exp128	-1.77
Dynasore 7μM R08 exp436	-1.76
GSK626616 14μM R08 exp485	-1.74
CoCl2 18μM R07 exp346	-1.73
Palbociclib 1μM R07 exp382	-1.72
Vinblastine 0.002μM R01 exp60	-1.72
Dorsomorphin 5μM R07 exp357	-1.71
INK128 0.2μM R02 exp70	-1.71
Olaparib 4μM R08 exp512	-1.71
Asunaprenir 3μM R07 exp336	1.75
Calcium Ionophore 0.4μM R07 exp342	1.76
GSK-J4 1μM R07 exp362	2.09
Lead acetate 2000μM R08 exp498 no dilution day6	2.66
Cerivastatin 0.15μM R05 exp226	2.74
TRAIL 50ng/ml R00 exp36	2.75
TRAIL 5ng/ml R00 exp35	2.94
Lead acetate 2000μM R08 exp497	3.04

Global Fraction of Cell Lines Where Essential: 41/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	1/28
bone	1/25
breast	4/33
central nervous system	4/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	3/21
liver	1/20
lung	2/75
lymphocyte	1/14
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	0/1
skin	8/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	1/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16462
Expression level (log2 read counts): 4.39

Expression Distribution

C1 1
PHD

integrator complex
snRNA 3-end processing
snRNA processing
snRNA metabolic process
ncRNA 3-end processing
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
RNA 3-end processing
ncRNA processing
ncRNA metabolic process
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process
gene expression