NFATC3

Gene Information

Official Symbol: NFATC3
Official Name: nuclear factor of activated T cells 3
Aliases and Previous Symbols: N/A
Entrez ID: 4775
UniProt: Q12968
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2010].
UniProt Summary: Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2. {ECO:0000269|PubMed:18815128}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Artemisinin 50μM R08 exp450	-2.62
SNS-032 15μM R08 exp443	-1.91
CFI-400945 25μM R08 exp469	-1.71
CR131-b 0.005μM R08 exp474	-1.71
Centrinone 0.5μM R07 exp343	-1.7
KU-0063794 3.8μM R02 exp71	1.71
3-Bromopyruvate 7μM R04 exp175	1.72
LY2090314 0.003μM R08 exp499	1.72
MK2206 4μM R08 exp504	1.73
Rapamycin 1μM R00 exp29	1.74
NFN1 1μM R03 exp100	1.75
D-Fructose 10000μM R06 exp279	1.78
Rapamycin 0.001μM R08 exp429	1.78
Nutlin-3A 1.6μM R06 exp294	1.81
Amiloride 100μM R08 exp447	1.82
LJH685 5μM R02 exp73	1.9
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	1.9
Rapamycin 2μM R07 exp306	2.05
Talazoparib 0.006μM R06 exp299	2.06
Milciclib 2μM R08 exp502	2.09
INK128 0.2μM R02 exp70	2.13
GSK2606414 1μM R05 exp236	2.16
Vemurafenib 6.6μM R02 exp89	2.3
Vincristine 0.0005μM R04 exp190	2.33
Oligomycin-A 2μM R00 exp25	2.6
Erlotinib 10μM R05 exp216	2.7
Rapamycin 10μM R00 exp30	3.52
Thapsigargin 0.005μM R07 exp407	4.34

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3329
Expression level (log2 read counts): 6.7

Expression Distribution

Gene	Correlation
PPP3R1	0.655
PPP3CA	0.632
ITPR1	0.547
RRM1	0.517
POLDIP2	0.417

negative regulation of vascular smooth muscle cell differentiation
calcineurin-NFAT signaling cascade
negative regulation of pri-miRNA transcription by RNA polymerase II
regulation of vascular smooth muscle cell differentiation
calcineurin-mediated signaling
negative regulation of smooth muscle cell differentiation
inositol phosphate-mediated signaling
nuclear transcription factor complex
regulation of smooth muscle cell differentiation
regulation of pri-miRNA transcription by RNA polymerase II
negative regulation of muscle cell differentiation
negative regulation of vasculature development
calcium-mediated signaling
cytokine production
regulation of muscle cell differentiation
Fc-epsilon receptor signaling pathway
transcription factor complex
Fc receptor signaling pathway
DNA-binding transcription repressor activity, RNA polymerase II-specific
regulation of vasculature development
transcription factor binding
second-messenger-mediated signaling
chromatin binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
immune response-regulating cell surface receptor signaling pathway
inflammatory response
RNA polymerase II proximal promoter sequence-specific DNA binding
immune response-regulating signaling pathway
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of cell differentiation
negative regulation of transcription by RNA polymerase II
negative regulation of developmental process
nucleobase-containing compound biosynthetic process
regulation of immune response
heterocycle biosynthetic process
aromatic compound biosynthetic process