PIK3R4
Gene Information
- Official Symbol: PIK3R4
- Official Name: phosphoinositide-3-kinase regulatory subunit 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 30849
- UniProt: Q99570
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Regulatory subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (PubMed:20643123). {ECO:0000269|PubMed:20643123}.
Pfam Domains GO Terms
Pfam Domains
| WD40 |
| Pkinase Tyr |
| Pkinase |
GO Terms
| nucleus-vacuole junction |
| phosphatidylinositol 3-kinase complex, class III, type I |
| phosphatidylinositol 3-kinase complex, class III, type II |
| autophagy of peroxisome |
| phosphatidylinositol 3-kinase complex, class III |
| toll-like receptor 9 signaling pathway |
| late endosome to vacuole transport |
| receptor catabolic process |
| positive regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of lipid kinase activity |
| protein targeting to vacuole |
| cellular response to glucose starvation |
| establishment of protein localization to vacuole |
| positive regulation of phospholipid metabolic process |
| regulation of phosphatidylinositol 3-kinase activity |
| protein localization to vacuole |
| regulation of lipid kinase activity |
| autophagosome |
| phagocytic vesicle membrane |
| regulation of phospholipid metabolic process |
| regulation of cytokinesis |
| toll-like receptor signaling pathway |
| axoneme |
| receptor metabolic process |
| phosphatidylinositol biosynthetic process |
| late endosome |
| pattern recognition receptor signaling pathway |
| positive regulation of lipid metabolic process |
| vacuolar transport |
| cellular response to starvation |
| microtubule cytoskeleton |
| macroautophagy |
| regulation of cell division |
| phosphatidylinositol metabolic process |
| response to starvation |
| glycerophospholipid biosynthetic process |
| glycerolipid biosynthetic process |
| innate immune response-activating signal transduction |
| cellular response to nutrient levels |
| protein kinase activity |
| phospholipid biosynthetic process |
| activation of innate immune response |
| process utilizing autophagic mechanism |
| autophagy |
| cellular response to extracellular stimulus |
| glycerophospholipid metabolic process |
| cellular response to external stimulus |
| positive regulation of innate immune response |
| protein targeting |
| positive regulation of response to biotic stimulus |
| protein serine/threonine kinase activity |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| regulation of lipid metabolic process |
| establishment of protein localization to organelle |
| regulation of innate immune response |
| positive regulation of defense response |
| response to nutrient levels |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| immune response-activating signal transduction |
| positive regulation of kinase activity |
| lipid biosynthetic process |
| immune response-regulating signaling pathway |
| positive regulation of response to external stimulus |
| activation of immune response |
| positive regulation of transferase activity |
| intracellular membrane-bounded organelle |
| protein localization to organelle |
| regulation of cell cycle process |
| regulation of defense response |
| regulation of multi-organism process |
| positive regulation of immune response |
| regulation of kinase activity |
| organophosphate metabolic process |
| cellular lipid metabolic process |
| protein phosphorylation |
| regulation of transferase activity |
| intracellular protein transport |
| macromolecule catabolic process |
| positive regulation of phosphorylation |
| regulation of response to external stimulus |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of cell cycle |
| lipid metabolic process |
| phosphorylation |
| positive regulation of catalytic activity |
| regulation of response to stress |
| ATP binding |
| protein transport |
| intracellular transport |
| peptide transport |
| amide transport |
| cellular protein localization |
| regulation of phosphorylation |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of immune system process |
| cellular response to stress |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| SRP14 | 0.516 |
| GTF3C6 | 0.507 |
| CHCHD4 | 0.472 |
| TRIAP1 | 0.47 |
| AARS | 0.462 |
| GTF3C2 | 0.462 |
| UAP1 | 0.461 |
| THG1L | 0.456 |
| SEC61G | 0.454 |
| RTCB | 0.454 |
| APAF1 | 0.454 |
| KDSR | 0.453 |
| CBFB | 0.451 |
| RNMT | 0.45 |
| RBMX2 | 0.448 |
| HCCS | 0.444 |
| GMPPB | 0.442 |
| NAE1 | 0.441 |
| DHRSX | 0.44 |
| CTDNEP1 | 0.437 |
| DOLK | 0.435 |
| DPAGT1 | 0.434 |
| EIF4E | 0.434 |
| RPTOR | 0.429 |
| GTF3C4 | 0.428 |
| PPA2 | 0.428 |
| RAD1 | 0.428 |
| DDX20 | 0.428 |
| ALG1 | 0.426 |
| GEMIN6 | 0.424 |
| NBN | 0.423 |
| TTI2 | 0.423 |
| BAP1 | 0.421 |
| DOHH | 0.419 |
| ATXN10 | 0.417 |
| UHRF1 | 0.417 |
| TIMM22 | 0.416 |
| GFPT1 | 0.416 |
| LSM10 | 0.414 |
| SNAPC5 | 0.414 |
| MTOR | 0.413 |
| VRK1 | 0.412 |
| CEPT1 | 0.412 |
| PMM2 | 0.412 |
| ELP2 | 0.41 |
| CNOT4 | 0.405 |
| FAF2 | 0.405 |
| ALG13 | 0.402 |
| TPRKB | 0.402 |
| PELO | 0.402 |
| HARS | 0.402 |
| ATP2A2 | 0.401 |
| CASP9 | 0.401 |
| ENO1 | 0.4 |
| GEMIN7 | 0.4 |
| CCT7 | 0.4 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 16/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 1/28 |
| bone | 1/26 |
| breast | 1/33 |
| central nervous system | 1/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 0/21 |
| liver | 2/20 |
| lung | 3/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 5336
- Expression level (log2 read counts): 6.73
Expression Distribution
PIK3R4 Expression in NALM6 Cells: 6.73
