SNRPF

Entrez Summary: N/A
UniProt Summary: Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
2-Deoxy-D-glucose 800μM R05 exp214	-2.05
Centrinone 0.5μM R07 exp343	-1.9
Rotenone 2μM R00 exp33	-1.87
BI-6727 0.0125μM R03 exp97	-1.86
Actinomycin-D 0.001μM R00 exp3	-1.84
Citral 75μM R06 exp275	-1.82
Mdivi-1 15μM R05 exp217	-1.81
Nifuroxazide 1μM R01 exp51	1.7
HMS-I2 10μM R06 exp288	1.73
All-trans-Retinoic-Acid 8μM R07 exp333	1.77
THZ531 0.225μM R08 exp444	1.78
VE-822 0.04μM R06 exp300	1.8
Betulinic acid 10 to 15μM on day4 R05 exp222	1.84
Trichostatin-A 0.06μM R07 exp415	1.84
Apcin 25μM plus proTAME 2μM R04 exp177	1.85
Thioridazine 5μM R08 exp530	1.86
Nicotinamide 2000μM R01 exp50	1.97
BS-181 20μM R08 exp461	1.98
Dynasore 7μM R08 exp436	2.03
Bortezomib 0.005μM R00 exp6	2.1
Cisplatin 0.35μM R06 exp273	2.12
HMS-I2 1μM R06 exp286	2.12
5-Azacytidine 2μM R07 exp330	2.13
Rifampicin 1μM R00 exp31	2.21
Ibrutinib 1μM R07 exp372	2.29
Hydroxyurea 15μM R06 exp289	2.42
Rifampicin 10μM R00 exp32	2.98
Docosahexaenoic-acid 50μM R07 exp356	3
CVT-10216 0.1μM R06 exp278	3.47

Global Fraction of Cell Lines Where Essential: 726/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	28/28
blood	28/28
bone	25/25
breast	33/33
central nervous system	56/56
cervix	4/4
colorectal	17/17
esophagus	13/13
fibroblast	1/1
gastric	15/15
kidney	21/21
liver	20/20
lung	75/75
lymphocyte	14/14
ovary	26/26
pancreas	24/24
peripheral nervous system	16/16
plasma cell	15/15
prostate	1/1
skin	24/24
soft tissue	7/7
thyroid	2/2
upper aerodigestive	22/22
urinary tract	29/29
uterus	5/5

Expression Distribution

Gene	Correlation
GOLGA6L1	0.467
IK	0.445

pICln-Sm protein complex
U7 snRNP
small nucleolar ribonucleoprotein complex
U4 snRNP
methylosome
small nuclear ribonucleoprotein complex
SMN-Sm protein complex
U1 snRNP
U12-type spliceosomal complex
histone mRNA metabolic process
U2-type catalytic step 2 spliceosome
U4/U6 x U5 tri-snRNP complex
termination of RNA polymerase II transcription
spliceosomal snRNP assembly
U2-type precatalytic spliceosome
DNA-templated transcription, termination
catalytic step 2 spliceosome
spliceosomal complex
import into nucleus
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
nucleocytoplasmic transport
nuclear transport
mRNA splicing, via spliceosome
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
RNA splicing, via transesterification reactions
RNA splicing
ribonucleoprotein complex biogenesis
mRNA processing
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
mRNA metabolic process
cellular protein-containing complex assembly
RNA processing
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process