UROD

Entrez Summary: This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010].
UniProt Summary: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 135/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	10/28
bone	3/26
breast	6/33
central nervous system	2/56
cervix	0/4
colorectal	4/17
esophagus	1/13
fibroblast	0/1
gastric	5/16
kidney	2/21
liver	1/20
lung	18/75
lymphocyte	10/16
ovary	3/26
pancreas	6/24
peripheral nervous system	1/16
plasma cell	10/15
prostate	0/1
skin	2/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	6/29
uterus	1/5

Expression Distribution

uroporphyrinogen decarboxylase activity
protoporphyrinogen IX biosynthetic process
protoporphyrinogen IX metabolic process
heme biosynthetic process
porphyrin-containing compound biosynthetic process
tetrapyrrole biosynthetic process
heme metabolic process
porphyrin-containing compound metabolic process
pigment biosynthetic process
tetrapyrrole metabolic process
pigment metabolic process
cofactor biosynthetic process
cofactor metabolic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process