ZNF219

Gene Information

Official Symbol: ZNF219
Official Name: zinc finger protein 219
Aliases and Previous Symbols: N/A
Entrez ID: 51222
UniProt: Q9P2Y4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the Kruppel-like zinc finger gene family. The encoded protein functions as a transcriptional repressor of the high mobility group nucleosome binding domain 1 protein, which is associated with transcriptionally active chromatin. [provided by RefSeq, Apr 2017].
UniProt Summary: Transcriptional regulator (PubMed:14621294, PubMed:19549071). Recognizes and binds 2 copies of the core DNA sequence motif 5'-GGGGG-3' (PubMed:14621294). Binds to the HMGN1 promoter and may repress HMGN1 expression (PubMed:14621294). Regulates SNCA expression in primary cortical neurons (PubMed:19549071). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q6IQX8, ECO:0000269|PubMed:14621294, ECO:0000269|PubMed:19549071}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
VE-822 0.04μM R06 exp300	-2.22
42°C R08 exp539	-1.74
LLY-283 2.6μM R06 exp290	-1.74
Menadione 5μM R06 exp292	-1.7
UM131593 0.1μM R01 exp58	1.74
A-769662 20μM R07 exp331	1.79
YM155 0.0002μM R01 exp61	1.82
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	1.96
Parthenolide 2.5μM R05 exp238	1.99
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.14
Nifuroxazide 1μM R01 exp51	2.18
NFN1 0.1μM R01 exp49	2.39

Gene	Correlation
TCEB3CL2	0.486
TBC1D3H	0.465
C14orf93	0.461
TBC1D3F	0.461
C1QTNF9B	0.45
CGB2	0.445
VASN	0.44
RRN3	0.437
NAPA	0.436
TBC1D3	0.435
ZMAT5	0.433
TCEB3CL	0.429
TRIM52	0.42
NCAPG	0.418
TCEB3C	0.417
TBC1D3I	0.415
TBC1D3K	0.415
TBC1D3E	0.415
TBC1D3L	0.415
PLA2G4F	0.413
WDR87	0.413
TBC1D3G	0.411
BRIX1	0.409
PSMB2	0.408
AKIRIN2	0.405
RPS7	0.402
RFXANK	0.401
TBC1D3C	0.4

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2422
Expression level (log2 read counts): 3.05

Expression Distribution

histamine receptor activity
limb bud formation
positive regulation of chondrocyte differentiation
positive regulation of cartilage development
regulation of chondrocyte differentiation
regulation of cartilage development
limb morphogenesis
appendage morphogenesis
limb development
appendage development
DNA-binding transcription repressor activity, RNA polymerase II-specific
regulation of neurotransmitter levels
RNA polymerase II proximal promoter sequence-specific DNA binding
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
DNA-binding transcription factor activity
negative regulation of transcription by RNA polymerase II
anatomical structure formation involved in morphogenesis
positive regulation of cell differentiation
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription by RNA polymerase II
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
organic cyclic compound biosynthetic process
G protein-coupled receptor signaling pathway
negative regulation of RNA metabolic process
positive regulation of developmental process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
cellular nitrogen compound biosynthetic process