KIF18B

Entrez Summary: N/A
UniProt Summary: In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules. {ECO:0000269|PubMed:20600703, ECO:0000269|PubMed:21820309}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Taxol 0.004μM R03 exp103	-5.38
S-trityl-L-cysteine 0.5μM R05 exp243	-5.37
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-4.56
Epothilone-B 0.0015μM R05 exp231	-4.26
Docetaxel 0.002μM R01 exp45	-3.67
Taxol 0.002μM R01 exp54	-2.82
Cabazitaxel 0.001μM R05 exp223	-2.78
Centrinone 0.5μM R07 exp343	-2.39
Chlorpromazine 10μM R07 exp344	-2.36
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	-2.13
2-Methoxyestradiol 0.55μM R07 exp310	2.48
Quercetin 20μM R08 exp517	2.8
2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312	2.89
HMS-I1 1μM R01 exp46	3.13
BML-284 0.09μM R08 exp460	3.29
2-Methoxyestradiol 0.55 to 0.75μM on day4 R07 exp311	4.37
UM131593 0.2μM R03 exp106	7.08
UMK57 1μM R01 exp59	7.13
Mdivi-1 15μM R05 exp217	7.96

Global Fraction of Cell Lines Where Essential: 84/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	1/28
bone	4/26
breast	1/33
central nervous system	15/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	8/21
liver	2/20
lung	4/75
lymphocyte	1/16
ovary	3/26
pancreas	0/24
peripheral nervous system	2/16
plasma cell	2/15
prostate	0/1
skin	4/24
soft tissue	2/9
thyroid	1/2
upper aerodigestive	5/22
urinary tract	5/29
uterus	1/5

Expression Distribution