Table of Contents

PF-06409577 20μM R07 exp389

Mechanism of Action

Activates AMPK, lowers cholesterol levels in NAFLD/NASH preclinical models

Technical Notes

Compound References

  • PubChem Name: 6-Chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid
  • Synonyms: N/A
  • CAS #: 1467057-23-3
  • PubChem CID: 71748255
  • IUPAC: 6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
  • INCHI Name: InChI=1S/C19H16ClNO3/c20-16-9-17-14(15(10-21-17)18(22)23)8-13(16)11-2-4-12(5-3-11)19(24)6-1-7-19/h2-5,8-10,21,24H,1,6-7H2,(H,22,23)
  • INCHI Key: FHQXLWCFSUSXBF-UHFFFAOYSA-N
  • Molecular Weight: 341.8
  • Canonical SMILES: C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=C3)C(=CN4)C(=O)O)Cl)O
  • Isomeric SMILES: N/A
  • Molecular Formula: C19H16ClNO3

Compound Supplier

  • Supplier Name: Med Chem Express
  • Catalog #: HY-103683
  • Lot #: 27233

Compound Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C19H16ClNO3 364.07109; found 364.07064

Dose Response Curve

  • Platform ID: PF-06409577
  • Min: -1.6834; Max: 29.3429





IC Concentration (µM)
IC10 N/A
IC20 N/A
IC30 N/A
IC40 N/A
IC50 N/A
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
1/10ScoresViewViewViewViewView