BCOR

Entrez Summary: The protein encoded by this gene was identified as an interacting corepressor of BCL6, a POZ/zinc finger transcription repressor that is required for germinal center formation and may influence apoptosis. This protein selectively interacts with the POZ domain of BCL6, but not with eight other POZ proteins. Specific class I and II histone deacetylases (HDACs) have been shown to interact with this protein, which suggests a possible link between the two classes of HDACs. Several transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome Y.[provided by RefSeq, Jun 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
THZ531 0.11 to 0.175μM on day4 R07 exp413	-2.75
Pterostilbene 16μM R02 exp78	-2.69
5-Fluorouracil 20μM R00 exp2	-2.68
Brefeldin A 0.02μM R00 exp8	-2.5
UM0129480 7μM R02 exp85	-2.5
Bortezomib 0.05μM R00 exp7	-2.36
CoCl2 18μM R07 exp346	-2.3
Pimelic-diphenylamide-106 5μM R00 exp28	-2.28
DABN 20μM R00 exp17	-2.26
TIC10 10μM R08 exp532	-2.21
GSK626616 14μM R08 exp485	-2.19
Nocodazole 0.2μM R00 exp24	-2.17
THZ1 0.06μM R08 exp531	-2.15
Bafilomycin-A1 0.009μM R08 exp454	-2.13
MK-1775 0.32μM R02 exp75	-2.13
CI-1040 9.5μM R08 exp472	-2.11
Rotenone 2μM R00 exp33	-2.07
THZ531 0.11μM R07 exp409	-2.06
UMK57 1μM R01 exp59	-2.06
Actinomycin-D 0.001μM R00 exp3	-1.99
Etoposide 1μM R00 exp19	-1.99
Aphidicolin 0.4μM R08 exp440	-1.98
42°C R08 exp539	-1.96
Vinblastine 0.002μM R01 exp60	-1.95
THZ531 0.225μM R08 exp444	-1.92
Nocodazole 0.2μM R02 exp64	-1.89
LY2090314 0.003μM R08 exp500 no dilution day6	-1.86
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.83
Clomiphene 4.4μM R02 exp68	-1.73
LJH685 50μM R08 exp433	-1.73
Ammonium tetrathiomolybdate 10μM R08 exp448	-1.71
Monensin 0.3μM R08 exp507	-1.71
Taxol 0.004μM R03 exp103	-1.71
Actinomycin-D 0.01μM R00 exp4	-1.7
ML-792 0.2μM R08 exp505	1.8
Bisphenol S 100μM R08 exp458	1.81
Pyrazinamide 100μM R08 exp516	1.81
Rapamycin 10μM R00 exp30	1.82
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.87
IWR1 50μM R08 exp495	2.01
Pomalidomide 20μM R07 exp391	2.12
GSK-J5 1.5μM R08 exp484	2.23
TRAIL 5ng/ml R00 exp35	2.43
Aminopterin 0.005μM R07 exp335	2.98

Global Fraction of Cell Lines Where Essential: 1/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	1/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution