CMTR1

Entrez Summary: N/A
UniProt Summary: S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. {ECO:0000269|PubMed:18533109, ECO:0000269|PubMed:20713356, ECO:0000269|PubMed:21310715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 445/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	18/28
blood	15/28
bone	16/26
breast	14/33
central nervous system	42/56
cervix	0/4
colorectal	7/17
esophagus	8/13
fibroblast	0/1
gastric	9/16
kidney	11/21
liver	13/20
lung	45/75
lymphocyte	8/16
ovary	19/26
pancreas	22/24
peripheral nervous system	9/16
plasma cell	7/15
prostate	0/1
skin	10/24
soft tissue	5/9
thyroid	1/2
upper aerodigestive	19/22
urinary tract	19/29
uterus	4/5

Expression Distribution