MNS1

Gene Information

Official Symbol: MNS1
Official Name: meiosis specific nuclear structural 1
Aliases and Previous Symbols: N/A
Entrez ID: 55329
UniProt: Q8NEH6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Benzoate 10000μM R08 exp455	-3.11
Rapamycin 1μM R00 exp29	-2.58
CAY10603 0.55μM R08 exp467	-2.51
Sucrose 20000μM R06 exp298	-2.37
NFN1 1μM R03 exp100	-2.28
3-Bromopyruvate 7μM R04 exp175	-2.24
GSK-J4 1-1.25μM to day4 R07 exp363	-2.2
MSC2530818 10μM R07 exp379	-2.14
Apcin 50 to 100μM on day4 R04 exp176	-2.08
Ixabepilone 0.004 to 0.005μM on day4 R04 exp184	-2
Isonicotinamide 500μM R03 exp129	-1.98
Chloramphenicol 2μM R00 exp12	-1.93
Vincristine 0.0005μM R04 exp190	-1.93
Nifuroxazide 5μM R03 exp102	-1.91
FBS-Wisent 0.1 R07 exp426	-1.91
PF-06409577 20μM R07 exp389	-1.83
Caffeine 2600μM R08 exp463	-1.8
Doxycycline 10μM R00 exp18	-1.75
UNC2400 2μM R03 exp156	-1.73
GSK-J4 1.5μM R08 exp441	-1.71
DABN racemic mixture R03 exp93	1.78
Monensin 0.3μM R08 exp507	2.01
FK-506 30μM R07 exp359	2.24
2-Deoxy-D-glucose 800μM R05 exp214	2.28

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18847
Expression level (log2 read counts): 5.09

Expression Distribution