MRPL27
Gene Information
- Official Symbol: MRPL27
- Official Name: mitochondrial ribosomal protein L27
- Aliases and Previous Symbols: N/A
- Entrez ID: 51264
- UniProt: Q9P0M9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Ribosomal L27 |
GO Terms
| mitochondrial large ribosomal subunit |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| RNA binding |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PT-1 25μM R07 exp392 | -2.08 |
| Sulforaphane 9μM R08 exp526 no dilution day6 | -1.75 |
| Docosahexaenoic-acid 50μM R07 exp356 | -1.74 |
| BS-181 20μM R08 exp461 | -1.73 |
| GSK-J4 1.5μM R08 exp441 | 2 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPL21 | 0.531 |
| HSD17B10 | 0.526 |
| MRPS14 | 0.522 |
| COX16 | 0.505 |
| SARS2 | 0.496 |
| ELAC2 | 0.495 |
| DAP3 | 0.495 |
| MRPS16 | 0.495 |
| SELRC1 | 0.495 |
| MRP63 | 0.488 |
| SLC25A26 | 0.483 |
| YARS2 | 0.474 |
| MRPL23 | 0.468 |
| SUPV3L1 | 0.466 |
| MRPS6 | 0.465 |
| BCS1L | 0.464 |
| AASDHPPT | 0.459 |
| MRPS21 | 0.458 |
| FARS2 | 0.458 |
| RPUSD4 | 0.454 |
| MRPS5 | 0.451 |
| MRPL15 | 0.45 |
| SLC25A19 | 0.449 |
| SCO2 | 0.446 |
| MRPS2 | 0.445 |
| HARS2 | 0.444 |
| TUFM | 0.443 |
| MRPS18A | 0.437 |
| NDUFB5 | 0.436 |
| TRIAP1 | 0.436 |
| UQCRC2 | 0.436 |
| DARS2 | 0.433 |
| ATXN10 | 0.432 |
| QRSL1 | 0.431 |
| MRPS9 | 0.428 |
| COX6B1 | 0.427 |
| MRPS26 | 0.427 |
| MRPS25 | 0.426 |
| RNASEH1 | 0.426 |
| TPK1 | 0.424 |
| COA6 | 0.42 |
| ATIC | 0.42 |
| NDUFA3 | 0.419 |
| TFAM | 0.418 |
| RBFA | 0.416 |
| PDSS1 | 0.416 |
| ZRSR2 | 0.415 |
| KIAA0391 | 0.415 |
| MRPS34 | 0.414 |
| NARS2 | 0.412 |
| MRPL53 | 0.41 |
| MRPL47 | 0.408 |
| TOMM22 | 0.408 |
| PPA2 | 0.408 |
| COX17 | 0.406 |
| VARS2 | 0.405 |
| WBSCR16 | 0.405 |
| TARS2 | 0.404 |
| MARS2 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 158/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 4/28 |
| blood | 4/28 |
| bone | 5/26 |
| breast | 9/33 |
| central nervous system | 9/56 |
| cervix | 1/4 |
| colorectal | 7/17 |
| esophagus | 6/13 |
| fibroblast | 0/1 |
| gastric | 5/16 |
| kidney | 1/21 |
| liver | 10/20 |
| lung | 11/75 |
| lymphocyte | 4/16 |
| ovary | 3/26 |
| pancreas | 1/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 3/24 |
| soft tissue | 2/9 |
| thyroid | 1/2 |
| upper aerodigestive | 5/22 |
| urinary tract | 7/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 2905
- Expression level (log2 read counts): 4.98
Expression Distribution
MRPL27 Expression in NALM6 Cells: 4.98
