MRPL51
Gene Information
- Official Symbol: MRPL51
- Official Name: mitochondrial ribosomal protein L51
- Aliases and Previous Symbols: N/A
- Entrez ID: 51258
- UniProt: Q4U2R6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| MRP-L51 |
GO Terms
| mitochondrial ribosome |
| mitochondrial large ribosomal subunit |
| mitochondrial translational elongation |
| mitochondrial translational termination |
| translational termination |
| mitochondrial translation |
| translational elongation |
| cellular protein complex disassembly |
| mitochondrial gene expression |
| structural constituent of ribosome |
| protein-containing complex disassembly |
| translation |
| mitochondrial inner membrane |
| cellular component disassembly |
| peptide biosynthetic process |
| amide biosynthetic process |
| peptide metabolic process |
| cellular amide metabolic process |
| mitochondrion |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| protein-containing complex subunit organization |
| gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| DABN 2μM R00 exp16 | -1.77 |
| RS-1 10μM R08 exp519 | -1.75 |
| Arsenate 40μM R06 exp264 | 1.7 |
| CR131-b 0.005μM R08 exp474 | 1.74 |
| A-196 10μM R03 exp114 | 1.76 |
| Hydroxyurea 100μM R07 exp329 | 1.79 |
| Thimerosal 0.85μM R08 exp529 | 1.81 |
| Rapamycin 10μM R00 exp30 | 2.09 |
| BI-6727 0.0125μM R03 exp97 | 2.11 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| MRPS21 | 0.51 |
| MRPL45 | 0.509 |
| RARS2 | 0.485 |
| NARS2 | 0.484 |
| MRPL47 | 0.477 |
| PARS2 | 0.476 |
| DAP3 | 0.473 |
| SELRC1 | 0.467 |
| MRPS12 | 0.466 |
| GFM1 | 0.464 |
| METTL17 | 0.463 |
| RPUSD3 | 0.459 |
| MARS2 | 0.457 |
| MRPS6 | 0.452 |
| PTCD3 | 0.449 |
| MRPL3 | 0.448 |
| WBSCR16 | 0.446 |
| EARS2 | 0.446 |
| AARS2 | 0.445 |
| YARS2 | 0.443 |
| HSD17B10 | 0.441 |
| MRPL21 | 0.44 |
| MRPS16 | 0.437 |
| MRPS7 | 0.435 |
| RBFA | 0.435 |
| TRUB2 | 0.432 |
| COA3 | 0.431 |
| PNPT1 | 0.427 |
| CARS2 | 0.425 |
| MRPL14 | 0.425 |
| MRPL42 | 0.421 |
| TUFM | 0.421 |
| MRPS14 | 0.416 |
| COX16 | 0.415 |
| MRPS28 | 0.413 |
| LARS2 | 0.413 |
| COX7B | 0.412 |
| MRPL20 | 0.412 |
| PET117 | 0.412 |
| PET112 | 0.412 |
| MRPS5 | 0.411 |
| MRPS27 | 0.411 |
| MRPS10 | 0.411 |
| HARS2 | 0.409 |
| COX17 | 0.407 |
| RPUSD4 | 0.407 |
| QRSL1 | 0.407 |
| MRPL23 | 0.406 |
| NDUFAF7 | 0.405 |
| FASTKD5 | 0.403 |
| RTN4IP1 | 0.402 |
| MRPS34 | 0.402 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 7/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 781
- Expression level (log2 read counts): 6.15
Expression Distribution
MRPL51 Expression in NALM6 Cells: 6.15
