MTA2
Gene Information
- Official Symbol: MTA2
- Official Name: metastasis associated 1 family member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9219
- UniProt: O94776
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May be involved in the regulation of gene expression as repressor and activator. The repression might be related to covalent modification of histone proteins.
Pfam Domains GO Terms
Pfam Domains
| GATA |
| ELM2 |
| BAH |
GO Terms
| NuRD complex |
| histone deacetylase activity |
| regulation of fibroblast migration |
| RNA polymerase II repressing transcription factor binding |
| histone deacetylase complex |
| nucleosomal DNA binding |
| DNA alkylation |
| DNA methylation |
| histone deacetylation |
| protein deacetylation |
| protein deacylation |
| macromolecule deacylation |
| RNA polymerase II transcription factor binding |
| DNA methylation or demethylation |
| transcription regulatory region sequence-specific DNA binding |
| ATP-dependent chromatin remodeling |
| DNA modification |
| histone deacetylase binding |
| chromatin assembly or disassembly |
| chromatin remodeling |
| regulation of signal transduction by p53 class mediator |
| transcription factor complex |
| nuclear chromatin |
| transcription corepressor activity |
| macromolecule methylation |
| transcription coactivator activity |
| methylation |
| histone modification |
| covalent chromatin modification |
| protein-containing complex |
| chromatin organization |
| DNA metabolic process |
| zinc ion binding |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| regulation of cell motility |
| regulation of locomotion |
| regulation of cellular component movement |
| chromosome organization |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| membrane |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 5/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/25 |
| breast | 1/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 2/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2202
- Expression level (log2 read counts): 7.92
Expression Distribution
MTA2 Expression in NALM6 Cells: 7.92
