RHOH

Gene Information

Official Symbol: RHOH
Official Name: ras homolog family member H
Aliases and Previous Symbols: N/A
Entrez ID: 399
UniProt: Q15669
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013].
UniProt Summary: Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation of NF-kappa-B by TNF and IKKB and the activation of CRK/p38 by TNF. Inhibits activities of RAC1, RHOA and CDC42. Negatively regulates leukotriene production in neutrophils. {ECO:0000250, ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
TRAIL 50ng/ml R00 exp36	-2.6
Etoposide 1μM R00 exp19	-2.3
Rotenone 20μM R00 exp34	-1.83
Cytochalasin-B 5μM R07 exp349	-1.8
Tubacin 1.6μM R07 exp416	-1.8
TRAIL 5ng/ml R00 exp35	-1.79
Vemurafenib 6.6μM R02 exp89	-1.78
HMS-I1 10μM R06 exp256	1.7
CB-839 10μM R05 exp224	1.71
RS-1 10μM R08 exp519	1.73
Mubritinib 0.2μM R01 exp48	1.74
AICAR 240μM R05 exp211	1.75
Bortezomib 0.005μM R00 exp6	1.75
Bisphenol S 100μM R08 exp458	1.76
Rapamycin 0.001μM R08 exp429	1.77
Salubrinal 20μM R07 exp399	1.77
Rapamycin 2μM R07 exp306	1.78
UM0131023 0.05μM R05 exp248	1.8
Erlotinib 10μM R05 exp216	1.82
A-366 10μM R03 exp115	1.83
QNZ 0.01μM R08 exp439	1.87
EPZ-5676 30μM R05 exp233	1.88
Citral 75μM R06 exp275	1.89
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	1.96
iCRT14 30μM R08 exp492	1.99
Thimerosal 0.85μM R08 exp529	1.99
5-Azacytidine 2μM R07 exp330	2.02
THZ531 0.225μM R08 exp444	2.08
Arsenate 40μM R06 exp264	2.19
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	2.24
LY2090314 0.003μM R08 exp500 no dilution day6	2.25
LY2090314 0.003μM R08 exp499	2.34
Hippuristanol 0.12μM R08 exp489 no dilution day6	2.51
Nifuroxazide 5μM R03 exp102	2.53
Rucaparib 6.5μM R08 exp520	2.55
Citral 50μM R06 exp274	2.58
Benzoate 20000μM R08 exp456	2.62
B02 10μM R08 exp453	2.65
Aphidicolin 0.4μM R08 exp440	2.73
Hippuristanol 0.12μM R08 exp488	2.76
Amiloride 100μM R08 exp447	3.05
AICAR 240μM R03 exp116	3.07
MS023 2μM R03 exp134	3.1
Sulforaphane 9μM R08 exp525	3.24
ML-792 0.2μM R08 exp505	3.33
MLN-4924 0.2μM R00 exp21	3.33
Sulforaphane 9μM R08 exp526 no dilution day6	3.41
Benzoate 10000μM R08 exp455	3.56
Trimetrexate 0.03μM R08 exp535	4.02
Ethanol 0.01 R05 exp234	4.15

Gene	Correlation
PIK3CD	0.78
CD19	0.762
SYK	0.755
IGLL1	0.738
CD81	0.655
ERGIC1	0.655
CD79B	0.653
MAPKAP1	0.639
CD79A	0.629
RICTOR	0.627
AKT2	0.601
VEZF1	0.495
PDS5A	0.491
PDPK1	0.489
AKT1	0.487
MLST8	0.479
SSR3	0.446
GANAB	0.443
RBM41	0.424
PDCL	0.42
TOX4	0.409
MIDN	0.407
SSR2	0.402

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	1/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2334
Expression level (log2 read counts): 6.32

Expression Distribution