TAF1A

Official Symbol: TAF1A
Official Name: TATA-box binding protein associated factor, RNA polymerase I subunit A
Aliases and Previous Symbols: N/A
Entrez ID: 9015
UniProt: Q15573
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (pre- initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits. {ECO:0000269|PubMed:15970593, ECO:0000269|PubMed:7801123}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dimethyloxaloylglycine 11μM R07 exp314	-2.01
CCCP 0.1μM R00 exp10	-2
Nocodazole 0.02μM R00 exp23	-1.93
Epigallocatechin gallate 20μM R05 exp230	-1.91
NN-Diethyl-meta-toluamide 100μM R05 exp237	-1.89
Quinacrine 2.5μM R03 exp146	-1.84
Geldanamycin 0.015 to 0.05μM on day4 R07 exp317	-1.83
Rapamycin 2μM plus FK-506 5μM R07 exp308	-1.77
NN-Diethyl-meta-toluamide 500μM R08 exp438	-1.72
Hippuristanol 0.12μM R08 exp489 no dilution day6	-1.71

Global Fraction of Cell Lines Where Essential: 1/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	1/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution