TSPY1

Gene Information

Official Symbol: TSPY1
Official Name: testis specific protein Y-linked 1
Aliases and Previous Symbols: N/A
Entrez ID: 7258
UniProt: Q01534
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Many functional paralogs and pseudogenes of this gene are present in a cluster in humans, but only a single, nonfunctional orthologous gene is found in mouse. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016].
UniProt Summary: May be involved in sperm differentiation and proliferation. {ECO:0000269|PubMed:8923009}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Hinokiflavone 12μM R08 exp487	-2.15
DABN 20μM R00 exp17	-1.83
Etoposide 1μM R00 exp19	-1.77
Salinomycin 3.5μM R08 exp521	-1.77
Pimelic-diphenylamide-106 5μM R00 exp28	-1.73
THZ531 0.225μM R08 exp444	1.76
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	2.42

Gene	Correlation
TBC1D3G	0.529
POLR2J3	0.526
PRIM1	0.524
HGC6.3	0.52
TBC1D3F	0.515
PSMA6	0.509
TBC1D3H	0.506
TBC1D3C	0.498
RPL35	0.493
PSMB4	0.492
RUVBL2	0.483
EXOSC8	0.482
TBC1D3	0.48
RPS2	0.478
ATP6V1A	0.472
UPF1	0.472
GOLGA6L1	0.469
COL2A1	0.469
RRP7A	0.467
PSMB2	0.466
ORC6	0.457
RAD51	0.457
POLR2D	0.457
NPIPB5	0.456
POLA2	0.456
TCEB3CL2	0.456
PSMD2	0.455
TCEB3CL	0.454
CACTIN	0.453
CHD4	0.452
TBC1D3E	0.451
TBC1D3L	0.451
TBC1D3I	0.451
TBC1D3K	0.45
MT1E	0.45
C1QTNF9B	0.448
MYB	0.448
CTAGE4	0.447
RPL6	0.446
TCEB3C	0.444
CBWD3	0.441
GOLGA6L6	0.44
KRT78	0.439
RPL9	0.438
CBWD5	0.436
WDR75	0.436
HAP1	0.435
PSMA7	0.434
RRP15	0.434
PSMC6	0.432
TIMELESS	0.43
PSMC2	0.428
NOL12	0.428
RRN3	0.426
NBPF10	0.424
FBXW9	0.423
SUPT6H	0.422
PLA2G4F	0.419
C14orf93	0.419
TFIP11	0.418
TWISTNB	0.418
UQCRH	0.417
DTL	0.415
CBWD6	0.413
SNRPA1	0.413
WDR87	0.413
TSG101	0.411
NARFL	0.41
POLA1	0.409
RIOK2	0.408
COPB1	0.408
LAD1	0.407
HIVEP3	0.407
PSMC4	0.405
SMG1	0.405
FAM160A1	0.405
RPS14	0.405
CDC6	0.404
ORC1	0.404
DDX56	0.404
POLR2A	0.403
AATF	0.403
SF3A3	0.402
RPL17	0.401
OGFR	0.401
CCNA2	0.4
PSMC5	0.4

Essentiality in NALM6

Essentiality Rank: 2244
Expression level (log2 read counts): -7.68

Expression Distribution