Table of Contents

Docetaxel 0.001 to 0.002μM on day4 R04 exp159

Mechanism of Action

Inihibts microtubule depolymerization, semi-synthetic analog of the paclitaxel

Technical Notes

Protein References

  • PubChem Name: Docetaxel
  • Synonyms: RP-56976
  • CAS #: 114977-28-5
  • PubChem CID: 148124
  • IUPAC: [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
  • INCHI Name: InChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1
  • INCHI Key: ZDZOTLJHXYCWBA-VCVYQWHSSA-N
  • Molecular Weight: 807.9
  • Canonical SMILES: CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
  • Isomeric SMILES: CC1=C2[C@H](C(=O)[C@@]3([C@H](C[C@@H]4[C@]([C@H]3[C@@H]([C@@](C2(C)C)(C[C@@H]1OC(=O)[C@@H]([C@H](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)O
  • Molecular Formula: C43H53NO14

Protein Supplier

  • Supplier Name: Abcam
  • Catalog #: AB141248
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+Na)+ Calcd for C43H53NO14 830.33583; found 830.33216

Dose Response Curve

  • Platform ID: Docetaxel
  • Min: -5.4973; Max: 89.2431





IC Concentration (µM)
IC10 N/A
IC20 0.0008
IC30 0.0010
IC40 0.0013
IC50 0.0016
IC60 N/A
IC70 N/A
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
11/0ScoresViewViewViewViewView