Table of Contents

Dexamethasone 0.006μM R07 exp351

Mechanism of Action

Glucocorticoid receptor agonist, anti-inflammatory

Technical Notes

Protein References

  • PubChem Name: Dexamethasone
  • Synonyms: Hexadecadrol; Prednisolone F
  • CAS #: 50-02-2
  • PubChem CID: 5743
  • IUPAC: (8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
  • INCHI Name: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
  • INCHI Key: UREBDLICKHMUKA-CXSFZGCWSA-N
  • Molecular Weight: 392.5
  • Canonical SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
  • Isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)CO)O)C)O)F)C
  • Molecular Formula: C22H29FO5

Protein Supplier

  • Supplier Name: Sigma-Aldrich
  • Catalog #: D4902
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C22H29FO5 393.20718; found 393.2068

Dose Response Curve

  • Platform ID: Dexamethasone
  • Min: -4.7517; Max: 71.3612





IC Concentration (µM)
IC10 N/A
IC20 0.0111
IC30 0.0159
IC40 0.0223
IC50 0.0178
IC60 N/A
IC70 0.2312
IC80 N/A
IC90 N/A


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
10/12ScoresViewViewViewViewView