Table of Contents

YM155 0.001μM R08 exp432

Mechanism of Action

Inhibits expression of survivin, amongst other ascribed mechanisms

Technical Notes

Protein References

  • PubChem Name: Sepantronium bromide
  • Synonyms: Sepantronium bromide
  • CAS #: 781661-94-7
  • PubChem CID: 11178236
  • IUPAC: 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
  • INCHI Name: InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1
  • INCHI Key: QBIYUDDJPRGKNJ-UHFFFAOYSA-M
  • Molecular Weight: 443.3
  • Canonical SMILES: CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]
  • Isomeric SMILES: N/A
  • Molecular Formula: C20H19BrN4O3

Protein Supplier

  • Supplier Name: Selleck Chemicals
  • Catalog #: S1130
  • Lot #: N/A

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M)+ Calcd for C20 H19 N4 O3 363.14572; found 363.14685

Dose Response Curve

  • Platform ID: YM155
  • Min: -11.6044; Max: 94.1406





IC Concentration (µM)
IC10 0.0008
IC20 0.0010
IC30 0.0012
IC40 0.0015
IC50 0.0017
IC60 0.0019
IC70 0.0023
IC80 0.0027
IC90 0.0036


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
6/2ScoresViewViewViewViewView