Table of Contents

Arsenic trioxide 60μM R08 exp449

Mechanism of Action

Induces degradation of aberrant PML-RAR‘± fusion protein in acute promyelocytic leukemia

Technical Notes

Protein References

  • PubChem Name: 2,4,6,8,9,10-Hexaoxa-1,3,5,7-tetraarsatricyclo[3.3.1.13,7]decane
  • Synonyms: N/A
  • CAS #: 1327-53-3
  • PubChem CID: 518605
  • IUPAC: 2,4,6,8,9,10-hexaoxa-1,3,5,7-tetrarsatricyclo[3.3.1.13,7]decane
  • INCHI Name: InChI=1S/As4O6/c5-1-6-3-8-2(5)9-4(7-1)10-3
  • INCHI Key: KTTMEOWBIWLMSE-UHFFFAOYSA-N
  • Molecular Weight: 395.68
  • Canonical SMILES: O1[As]2O[As]3O[As]1O[As](O2)O3
  • Isomeric SMILES: N/A
  • Molecular Formula: As4O6

Protein Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: A774130
  • Lot #: 14-CGS-186-1

Protein Characterization

  • XRPD: Expected As2O3; found As2O3

Dose Response Curve

  • Platform ID: Arsenic_Oxide
  • Min: 14.1313; Max: 99.7631





IC Concentration (µM)
IC10 30.7900
IC20 46.5800
IC30 61.3300
IC40 76.8500
IC50 94.5200
IC60 116.3000
IC70 145.7000
IC80 191.8000
IC90 290.2000


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
2/8ScoresViewViewViewViewView