Table of Contents

Dihydrosphingosine 8μM R08 exp476

Mechanism of Action

Inhibits cytosolic phospholipase A2α (cPLA2α) activity

Technical Notes

Protein References

  • PubChem Name: Sphinganine
  • Synonyms: N/A
  • CAS #: 764-22-7
  • PubChem CID: 91486
  • IUPAC: (2S,3R)-2-aminooctadecane-1,3-diol
  • INCHI Name: InChI=1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
  • INCHI Key: OTKJDMGTUTTYMP-ZWKOTPCHSA-N
  • Molecular Weight: 301.5
  • Canonical SMILES: CCCCCCCCCCCCCCCC(C(CO)N)O
  • Isomeric SMILES: CCCCCCCCCCCCCCC[C@H]([C@H](CO)N)O
  • Molecular Formula: C18H39NO2

Protein Supplier

  • Supplier Name: Toronto Research Chemicals
  • Catalog #: D449400
  • Lot #: 2-UTS-154-1

Protein Characterization

  • HRMS (ESI-TOF) m/z: (M+H)+ Calcd for C18H39NO2 302.30536; found 302.30628

Dose Response Curve

  • Platform ID: Dihydrosphingosine
  • Min: -10.6873; Max: 99.7582





IC Concentration (µM)
IC10 8.3490
IC20 9.1120
IC30 9.6580
IC40 10.1300
IC50 10.5800
IC60 11.0600
IC70 11.5900
IC80 12.2900
IC90 13.4100


Screen Summary

Screen Results

Sensitive/Resistant hits (FDR<0.05)CRANKSScore PlotTop 30 GenesScreen SimilarityTop 30 Sensitive GO termsTop 30 Resistant GO terms
2/1ScoresViewViewViewViewView